Sample:
Lane 1: Mouse Cerebellum tissue lysates
Lane 2: Mouse Heart tissue lysates
Lane 3: Human 293T cell lysates
Lane 4: Human MCF-7 cell lysates
Lane 5: Human A549 cell lysates
Primary: Anti-FUNDC1 (bs-13227R) at 1/800 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa
- ￥1180 - 1980
- Bioss
- bs-13227R
- 2025年10月16日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 产品编号 | bs-13227R |
| 英文名称 | FUNDC1 Rabbit pAb |
| 中文名称 | X三体综合症相关蛋白FUNDC1抗体 |
| 英文别名 | FUN14 domain containing protein 1; FUN14 domain-containing protein 1; FUND1_HUMAN. |
| 产品应用 | WB=1:300-800 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse FUNDC1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 17 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies |
| 亚基 | Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP. |
| 亚细胞定位 | Mitochondrion outer membrane; Multi-pass membrane protein. |
| 组织特异性 | Widely expressed. |
| 翻译后修饰 | Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy. |
| 相似性 | Belongs to the FUN14 family. |
| 功能 | Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | FUNDC1 is a 155 amino acid protein belonging to the FUN14 family. The gene encoding FUNDC1 maps to human chromosome Xp11.3 and mouse chromosome X A1.2. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:300-800} |
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文献和实验该产品被引用文献
[IF={{ 9.8 }}] {Jian Li. et al. FUNDC1-mediated mitophagy triggered by mitochondrial ROS is partially involved in 1-nitropyrene-evoked placental progesterone synthesis inhibition and intrauterine growth retardation in mice. SCI TOTAL ENVIRON. 2024 Jan;908:168383} {WB} {Human}
[IF={{ 8.2 }}] {Sen Zeng. et al. Role of OGDH in Atophagy-IRF3-IFN-β pathway during classical swine fever virus infection. INT J BIOL MACROMOL. 2023 Sep;249:126443} {WB} {Pig}
[IF={{ 7.2 }}] {Lan Gao. et al. c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy. JACC-BASIC TRANSL SC. 2025 May;:} {IF} {Rat}
[IF={{ 4.011 }}] {Xu G et al. Fundc1 is necessary for proper body axis formation during embryogenesis in zebrafish. Sci Rep. 2019 Dec 11;9(1):18910.} {WB} {grass carp&Human}
[IF={{ 3.3 }}] {Tang Lihua. et al. FUNDC1 predicts Poor Prognosis and promotes Progression and Chemoresistance in Endometrial Carcinoma. J CANCER. 2024 Oct;15(20):6490-6504} {IHC} {Human}
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FUNDC1 Rabbit pAb(bs-13227R)-50ul/100ul
￥1180 - 1980
