- ￥2980
- Bioss
- bs-2539R-Cy3
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
STAT3 Rabbit pAb, BF555 conjugated(bs-20382R-BF555)-100ul
￥2980
human CD73 Mouse mAb, FITC conjugated(bsm-30125M-FITC)-25T/50T/100T
￥1180
GIP Rabbit pAb(bs-0098R)-50ul/100ul/200ul
￥1180LHX9 Rabbit pAb(bs-18246R)-50ul/100ul/200ul
￥1180Somatostatin 14 Rabbit pAb, BF680 conjugated(bs-11796R-BF680)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-2539R-Cy3 |
| 英文名称 | MuRF1 Rabbit pAb, Cy3 conjugated |
| 中文名称 | Cy3标记的肌肉细胞特异性泛素蛋白连接酶1抗体 |
| 英文别名 | MTrim63; uRF 1; MuRF-1; Muscle-specific RING finger protein 1; Muscle-specific RING finger protein 1; E3 ubiquitin-protein ligase TRIM63; FLJ32380; IRF; MURF1; MURF 1; MURF2; RNF28; SMRZ; Iris ring finger protein; Muscle specific ring finger protein 2; Ring finger protein 28; RNF28; SMRZ; Striated muscle RING zinc finger protein; TRIM 63; TRIM63; Tripartite motif containing 63; Tripartite motif containing protein 63; Ubiquitin ligase TRIM63. |
| 产品应用 | Flow-Cyt=2ug/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MuRF1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Heart > Contractility > Contractile Proteins > Myosins Cardiovascular > Heart > Contractility > Contractile Proteins > Troponin Cardiovascular > Heart > Hypertrophy Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > RING Finger E3 Ligase Epigenetics and Nuclear Signaling > Cell cycle > Ubiquitin ligases Epigenetics and Nuclear Signaling > Ubiquitin & Ubiquitin Like Modifiers > E3 Ubiquitin Ligases |
| 亚基 | Homodimer. Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with GNB2L1 and PRKCE. Interacts with CKM. |
| 亚细胞定位 | Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes. Localizes to the M- and Z-lines in skeletal muscle. |
| 组织特异性 | Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. |
| 相似性 | Contains 1 B box-type zinc finger._x000D_
Contains 1 COS domain._x000D_ Contains 1 RING-type zinc finger. |
| 功能 | E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {2ug/Test} |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
MuRF1 Rabbit pAb, Cy3 conjugated(bs-2539R-Cy3)-100ul
￥2980
