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HMGA2 Rabbit pAb, Biotin conju

gated(bs-0556R-Bio)-100ul
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  • ￥2980
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  • bs-0556R-Bio
  • 2026年01月04日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    产品编号bs-0556R-Bio
    英文名称HMGA2 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的高迁移率族蛋白A2抗体
    英文别名HMGA 2; BABL; High mobility group(nonhistone chromosomal) protein isoform I C; High mobility group(nonhistone chromosomal) protein isoform IC; High Mobility Group AT hook 2; High Mobility Group AT hook protein 2; High mobility group protein HMGI C; High mobility group protein HMGIC; High mobility group protein I, isoform C; HMGA 2; HMGI C; HMGIC; LIPO; Non histone chromosomal architectural protein HMGI C; Non histone chromosomal architectural protein HMGIC; Pygmy; STQTL9; HMGA2_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human HMGA2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell cycle > Cell differentiation

    Developmental Biology > Post embryonic development > Aging

    Epigenetics and Nuclear Signaling > Cell cycle > Cell Differentiation

    Epigenetics and Nuclear Signaling > Histones > HMGs

    Neuroscience > Cell Type Marker > Neural Stem Cell marker

    Neuroscience > Neurology process > Metabolism

    Neuroscience > Neurology process > Neurogenesis

    Stem Cells > Neural Stem Cells > Intracellular

    亚基Interacts with E4F1. Interacts with NEK2 (By similarity).
    亚细胞定位Nucleus.
    翻译后修饰Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2.
    相似性Belongs to the HMGA family._x000D_
    Contains 3 A.T hook DNA-binding domains.
    功能 Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

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