- ￥5800
- Proteintech
- 66495-1-PBS
- 2025年10月09日
- WB, IHC, Indirect ELISA
- Mouse
- human
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human SURVIVIN protein
- 亚型：
IgG1
- 保存条件：
Store at -80°C.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Mouse
- 应用范围：
WB, IHC, Indirect ELISA
- 靶点：
SURVIVIN
- 抗体英文名：
SURVIVIN Monoclonal antibody, PBS Only
- 抗体名：
SURVIVIN Monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
66495-1-PBS targets SURVIVIN in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, IHC, Indirect ELISA |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag20958 Product name: Recombinant human SURVIVIN protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 1-142 aa of BC008718 Sequence: MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | baculoviral IAP repeat-containing 5 |
| 别名 | BIRC5, IAP4, EPR 1, BIRC 5, Baculoviral IAP repeat-containing protein 5 |
| 计算分子量 | 16 kDa |
| 观测分子量 | 18 kDa |
| GenBank蛋白编号 | BC008718 |
| 基因名称 | Survivin |
| Gene ID (NCBI) | 332 |
| RRID | AB_2881860 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O15392 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Survivin, also called BIRC5, is a unique member of the inhibitor of apoptosis (IAP) protein family. Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy, but is completely absent in terminally differentiated cells. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.
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