- ￥2800
- Proteintech
- CL555-80206
- 2025年10月09日
- FC (Intra)
- Rabbit
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Recombinant
- 标记物：
CoraLite®555 Fluorescent Dye
- 适应物种：
human, mouse
- 宿主：
Rabbit
- 应用范围：
FC (Intra)
- 靶点：
Phospho-S6 Ribosomal protein (Ser236)
- 抗体英文名：
CoraLite®555-conjugated Phospho-S6 Ribosomal protein (Ser236) Recombinant monoclonal antibody
- 抗体名：
CoraLite®555-conjugated Phospho-S6 Ribosomal protein (Ser236) Recombinant monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive FC (Intra) detected in | Calyculin A treated HEK-293 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL555-80206 targets Phospho-S6 Ribosomal protein (Ser236) in FC (Intra) applications and shows reactivity with human, mouse samples.
| 经测试应用 | FC (Intra) |
| 经测试反应性 | human, mouse |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | ribosomal protein S6 |
| 别名 | RPS6, S6, RP S6, ribosomal protein S6, Phosphoprotein NP33 |
| 计算分子量 | 29 kDa |
| 观测分子量 | 32 kDa |
| GenBank蛋白编号 | BC000524 |
| 基因名称 | RPS6 |
| Gene ID (NCBI) | 6194 |
| RRID | AB_3084637 |
| 偶联类型 | CoraLite®555 Fluorescent Dye |
| 最大激发/发射波长 | 557 nm / 570 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P62753 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Ribosomal protein S6 (RPS6) is one of the components of the 40S ribosomal subunit. RPS6 has been functionally regarded as the stimulator and/or inhibitor of certain types of mRNA translation, as well as the regulator of cellular metabolisms, cells size, survival and proliferation. RPS6 is phosphorylated at multiple sites, comprised between Ser235 and Ser247, by the p70 rpS6 kinase (S6K) 1, which is a major downstream effector of the mammalian target of rapamycin complex 1 (mTORC1). Phosphorylation of RPS6 at the dual site Ser235/236 occurs also independently of mTORC1, via the p90 ribosomal S6 kinases (RSK), which are activated by the extracellular signal-regulated kinases (ERK). Recent studies performed in pancreatic β-cells identified PKA as an additional RPS6 kinase, specifically involved in the phosphorylation of Ser235/236. (PMID: 26490682, PMID: 21814187, PMID: 31112404). 80206-1-RR specifically recognizes the phosphorylation site of Ser236 or dual site Ser235/236.
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文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
. Biochem. J. 408:297‐315. Blenis, J., Kuo, C.J., and Erikson, R.L. 1987. Identification of a ribosomal protein S6 kinase regulated by transformation and growth‐promoting stimuli
VGALQAQ XGALQKE VGALKKE VGALKK- NH2 [ 33] 和 ACGGE VGALKAE VG ALKAQ IG AX-Q KQ IG ALQ KE VGALKK- NH2 [32]。 10. Ji 等使用了记为 N36 ( L 6 ) C 34 的猿猴免疫缺陷病毒 gp41 核心的重组模型， 其中的氨基端螺旋（N36 ) 构成中心的三聚盘绕螺旋，而羧基端螺旋（C34 ) 以反平行 的取向堆积到此盘绕螺旋三聚体的疏水凹槽中。N36 和 C34 被一短联结
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