- ￥5800
- Proteintech
- 68254-1-PBS
- 2025年10月09日
- WB, IF/ICC, FC (Intra), Indirect ELISA
- Mouse
- human
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human ABL1 protein
- 亚型：
IgG2b
- 保存条件：
Store at -80°C.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Mouse
- 应用范围：
WB, IF/ICC, FC (Intra), Indirect ELISA
- 靶点：
ABL1
- 抗体英文名：
ABL1 Monoclonal antibody, PBS Only
- 抗体名：
ABL1 Monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
68254-1-PBS targets ABL1 in WB, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, IF/ICC, FC (Intra), Indirect ELISA |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag26152 Product name: Recombinant human ABL1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 801-900 aa of NM_005157 Sequence: MIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP |
| 宿主/亚型 | Mouse / IgG2b |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | c-abl oncogene 1, receptor tyrosine kinase |
| 别名 | c ABL, JTK7, EC:2.7.10.2, ABL, Abelson tyrosine-protein kinase 1 |
| 计算分子量 | 123 kDa |
| 观测分子量 | 130 kDa |
| GenBank蛋白编号 | NM_005157 |
| 基因名称 | ABL1 |
| Gene ID (NCBI) | 25 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P00519 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ABL1, also named as ABL, JTK7, c-ABL and p150, belongs to the protein kinase superfamily, Tyr protein kinase family and ABL subfamily. ABL1 regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. ABL1 localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. It regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. ABL1 catalyze the reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The antibody is specific to ABL1.
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