- ￥5800
- Proteintech
- 83688-4-PBS
- 2025年10月09日
- WB, ELISA
- Rabbit
- mouse
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- 详细信息
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -80°C.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
mouse
- 宿主：
Rabbit
- 应用范围：
WB, ELISA
- 靶点：
CD126/IL-6R alpha
- 抗体英文名：
CD126/IL-6R alpha Recombinant monoclonal antibody, PBS Only
- 抗体名：
CD126/IL-6R alpha Recombinant monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
83688-4-PBS targets CD126/IL-6R alpha in WB, ELISA applications and shows reactivity with mouse samples.
| 经测试应用 | WB, ELISA |
| 经测试反应性 | mouse |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | interleukin 6 receptor |
| 别名 | CD126, IL-6R alpha, 240734D1, IL 6R alpha, IL 6R 1 |
| 计算分子量 | 468 aa, 52 kDa |
| 观测分子量 | 65 kDA |
| GenBank蛋白编号 | BC132684 |
| 基因名称 | IL-6R alpha |
| Gene ID (NCBI) | 3570 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | P08887 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R alpha, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R, the complex of IL-6 and IL-6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while IL-6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892).
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