- ￥2800
- Proteintech
- CL555-67447
- 2025年10月09日
- FC (Intra)
- Mouse
- Human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human MYC protein
- 亚型：
IgG1
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
CoraLite®555 Fluorescent Dye
- 适应物种：
Human, mouse, rat
- 宿主：
Mouse
- 应用范围：
FC (Intra)
- 靶点：
c-MYC
- 抗体英文名：
CoraLite®555-conjugated c-MYC Monoclonal antibody
- 抗体名：
CoraLite®555-conjugated c-MYC Monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive FC (Intra) detected in | K-562 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL555-67447 targets c-MYC in FC (Intra) applications and shows reactivity with Human, mouse, rat samples.
| 经测试应用 | FC (Intra) |
| 经测试反应性 | Human, mouse, rat |
| 免疫原 |
CatNo: Ag17519 Product name: Recombinant human MYC protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 16-454 aa of BC000141 Sequence: MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | v-myc myelocytomatosis viral oncogene homolog (avian) |
| 别名 | MYC, MRTL, Class E basic helix-loop-helix protein 39, c Myc, bHLHe39 |
| 计算分子量 | 49 kDa |
| 观测分子量 | 55-60 kDa |
| GenBank蛋白编号 | BC000141 |
| 基因名称 | MYC |
| Gene ID (NCBI) | 4609 |
| RRID | AB_3084630 |
| 偶联类型 | CoraLite®555 Fluorescent Dye |
| 最大激发/发射波长 | 557 nm / 570 nm |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P01106 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.
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文献和实验'）2 Fragment（Alexa Fluor® 555 Conjugate）#4413 Anti-Rabbit IgG（H+L）， F（ab'）2 Fragment（Alexa Fluor® 647 Conjugate）#4414 抗小鼠： Anti-Mouse IgG（H+L）， F（ab'）2 Fragment（Alexa Fluor® 488 Conjugate）#4408 Anti-Mouse IgG（H+L）， F（ab'）2 Fragment（Alexa Fluor
Inducing RNAi with siRNA Cocktails Generated by RNase III
and a number of nonspecific target genes (La, Ku-70, c-myc, ß-actin, and cdk-2) were compared in transfected and nontransfected cells. Figure 3 shows a 63% reduction in GAPDH levels but no detectable reduction in the other genes examined. These data suggest
繁多，有多方向分化特点，故形态复杂，除常见的成骨型、成软骨型、成纤维型外，尚有较罕见的恶纤维型、血管扩张型、小圆细胞型，髓内高分化型和富于巨细型的骨肉瘤。骨肉瘤虽多由 髓内发生，但也可由骨外膜发生，向外生长形成骨表面骨肉瘤。骨表面骨肉瘤近年来又根据其形态及恶性度的不同分成四个亚型，尽管各型有其形态特征，但在常规诊断 时还是有不少被误诊。肿瘤生物学研究表明，骨肉瘤中细胞DNA含量明显高于正常细胞，并具有一系列癌基因的改变，如骨肉瘤中75%的P53基因突变，mdm2、c-myc及 c-raf扩增
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