- ￥1350 - 3000
- Proteintech
- 27716-1-AP
- 2025年10月09日
- WB, IHC, IF-P, IP, ELISA
- Rabbit
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human PLIN1 protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse
- 宿主：
Rabbit
- 应用范围：
WB, IHC, IF-P, IP, ELISA
- 靶点：
Perilipin 1
- 抗体英文名：
Perilipin 1 Polyclonal antibody
- 抗体名：
Perilipin 1 Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | 3T3-L1 cells, MCF-7 cells, NIH/3T3 cells, mouse liver tissue |
| Positive IP detected in | NIH/3T3 cells |
| Positive IHC detected in | mouse brown adipose tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brown adipose tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:8000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Immunohistochemistry (IHC) | IHC : 1:200-1:800 |
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
27716-1-AP targets Perilipin 1 in WB, IHC, IF-P, IP, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, IHC, IF-P, IP, ELISA |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse, goat, sheep |
| 免疫原 |
CatNo: Ag26426 Product name: Recombinant human PLIN1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 91-200 aa of NM_001145311 Sequence: MACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESA |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | perilipin |
| 别名 | PLIN, PLIN1, PERI |
| 计算分子量 | 56 kDa |
| 观测分子量 | 62-67 kDa |
| GenBank蛋白编号 | NM_001145311 |
| 基因名称 | Perilipin 1 |
| Gene ID (NCBI) | 5346 |
| RRID | AB_3085989 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O60240 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
PLIN1, also known as Perilipin 1, PLIN, PERI, belongs to the perilipin family. PLIN1 is a hormonally-regulated phosphoprotein that encircles the lipid storage droplet in adipocytes and modulates adipocyte lipid metabolism (PMID: 2040638). PLIN1 is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in inhibiting lipolysis. PLIN1 is detected in adipocytes of white adipose tissue, visceral adipose tissue, and mammary gland (PMID: 27832861, 9521880). The deficiency of PLIN1 causes lipodystrophic syndromes, which disables the optimal accumulation of triglycerides in adipocytes that results in abnormal deposition of lipids in tissues such as skeletal muscle and liver. The storage of lipids in the liver leads to insulin resistance and hypertriglyceridemia (PMID: 21345103).
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文献和实验| Species | Application | Title |
|---|---|---|
| mouse | WB | Hum Gene Ther Kallistatin Improves High-Fat-Induced Insulin Resistance via Epididymal Adipose Tissue-Derived ExosomesAuthors - Zi-Wei Yang |
| human,mouse | WB | Metabolism Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver diseaseAuthors - Jiang Du |
| mouse | IHC | Cells Development of a Mouse Experimental System for the In Vivo Characterization of Bioengineered Adipose-Derived Stromal CellsAuthors - Taeko Ichise |
| goat | WB | Biol Reprod NR4A1-mediated regulation of lipid droplets in progesterone synthesis in goat luteal cells†Authors - Hao Yu |
| mouse | IF | J Plast Reconstr Aesthet Surg Poloxamer 188 washing of lipoaspirate improves fat graft survival: A comparative study in nude miceAuthors - Meiling Liu |
| sheep | WB | Front Vet Sci Profile of miRNAs induced during sheep fat tail development and roles of four key miRNAs in proliferation and differentiation of sheep preadipocytesAuthors - Wei Zhang |
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