(-)-喹吡罗盐酸盐

产品名：

(-)-喹吡罗盐酸盐

品牌：

Absin

货号：

abs42040097

保持条件：

Store at -20° C

浓度：

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免疫原：

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抗原名称：

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应用：

A selective agonist of D₂-like dopamine receptors

使用方法：

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产品描述：

(-)-Quinpirole hydrochloride is an ergoline small molecule selective agonist of D₂-like dopamine receptors. The D₂-like class includes the D2DR, D3DR and D4DR (D2, D3, and D4 dopamine receptors), and structural similarity of each of these receptor subtypes limits agonist selectivity to the D₂-like receptors as a group. Research of conditions of dopamine deficiency such as schizophrenia and Parkinson‘s disease is usually directed at the D₂-like dopamine receptors, and (-)-Quinpirole has been employed along with other D₂-like agonists in perturbing and elucidating the chemical landscape beneath these conditions. (-)-Quinpirole demonstrates a neuroprotective effect against glutamate excitotoxicity through D₂ receptor agonism, protecting cells from calcium influx, nitric oxide introduction and peroxynitrile generation, all thought to be mediators of glutamate excitotoxicity. The degeneration of dopaminergic neurons by oxygen free radical species is implicated in the progression of Parkinson‘s disease, and stimulation of D₂ receptors by (-)-Quinpirole demonstrated protection against and scavenging of the harmful radicals - this activity was blocked by both a D₂ receptor antagonist and a protein synthesis inhibitor, indicating that stimulation of the D₂ receptor signals the dopaminergic cell to produce radical-scavenging proteins for protection.

爱必信品牌介绍：

爱必信（上海）生物科技有限公司是一家从事生物学试剂及耗材的高新技术企业。公司秉承“为生命科学创造便利！为客户创造价值！为员工创造幸福人生！”的发展理念，拥有专业的产品研发质检团队、市场营销团队及先进仓储物流等管理团队。荣获2021年度上海市“专精特新”企业称号。

自营品牌Absin®，主要经营产品有：生化试剂（常用生化试剂、生物学实验常用试剂、荧光染料、激动剂/抑制剂，植物提取物）、细胞生物学（细胞培养产品、血清、基质胶、添加剂、检测试剂盒）、免疫学产品、分子生物学产品、实验室仪器/耗材、产品定制和检测服务。

Absin还提供一些独有的特色产品：霍乱毒素B亚单位（CTB）、 鸡胚提取物（CEE）、 牛脑垂体提取物、 呼吸爆发试剂盒、 多色免疫组化试剂盒、 mRNA原料等在业界深受客户喜欢。

Absin秉承踏实，务实，求精和不断创新的精神为中国科学家提供优质产品，努力打造属于中国自己的生物试剂品牌，为广大科学家提供更全面更丰富更优质的产品。

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