Rabbit anti-pan-AKT Polyclonal

别名：兔抗泛AKT多克隆抗体A synthesized peptide derived from Human AKT1(Accession P31749), corresponding to amino acid residues S422-Q445.WB: 1:500-1:2000, IF: 1:100-1:500, ICC: 1:100-1:500, ELISA: 1:20000-1:40000Store at -20 °C for one year. Avoid repeated freeze/thaw cyclesElisa,FlowCytometry,ICC,ICC-IF,IF,WB,other见优宁维官网RabbitHuman;Mouse;Rat;Pig

克隆性：见优宁维官网

产品描述：

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

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