- 询价
- Absin
- abs136523
- 上海
- 2025年08月26日
- Rabbit
- 见优宁维官网
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- 详细信息
- 技术资料
- 抗体名：
Rabbit anti-p65 Polyclonal mAb
- 抗体英文名：
Rabbit anti-p65 Polyclonal Antibody
- 靶点：
见优宁维官网
- 浓度：
1mg/ml
- 宿主：
Rabbit
- 适应物种：
见优宁维官网
- 保质期：
见优宁维官网
- 抗原来源：
见优宁维官网
- 级别：
优级
- 库存：
999
- 供应商：
Absin
- 标记物：
见优宁维官网
- 克隆性：
见优宁维官网
- 保存条件：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
- 免疫原：
A synthesized peptide derived from Human RELA(Accession Q04206), corresponding to amino acid residues G522-L545.
- 规格：
50ug///100ug
别名：兔抗p65多克隆抗体A synthesized peptide derived from Human RELA(Accession Q04206), corresponding to amino acid residues G522-L545.WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:100-1:500, ICC: 1:100-1:500, ELISA: 1:20000-1:40000Store at -20 °C for one year. Avoid repeated freeze/thaw cyclesElisa,FlowCytometry,ICC,ICC-IF,IF,IHC,WB,other见优宁维官网RabbitHuman;Mouse;Rat;Fish
克隆性：见优宁维官网
产品描述：
Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins (3-5). NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression (6-8). NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus (9-11). NF-κB assembly with IκB, as well as its DNA binding and transcriptional activity, are regulated by p300/CBP acetytransferases that principally target Lys218, Lys221 and Lys310 (12-14). This process is reciprocally regulated by histone deacetylases (HDACs); several HDAC inhibitors have been shown to activate NF-κB (12-14).
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