Rabbit anti-TNNT2 Polyclonal A

别名：兔抗TNNT2多克隆抗体A synthesized peptide derived from Human TNNT2(Accession P45379), corresponding to amino acid residues K268-K290.WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:100-500, ELISA: 1:20000-1:40000, ELISA: 1:20000-1:40000Store at -20 °C for one year. Avoid repeated freeze/thaw cyclesElisa,FlowCytometry,ICC,ICC-IF,IF,IHC,WB,other见优宁维官网RabbitHuman;Mouse;Rat

克隆性：见优宁维官网

产品描述：

Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI) (1). In response to β-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC (1-3). The tropomyosin binding subunit of the troponin complex TnT exists as different isoforms in slow skeletal muscle (ssTnT/TNNT1), fast skeletal muscle (fsTnT/TNNT3) and in cardiac muscle (cTnT/TNNT2). Each of these may also contain multiple alternatively spliced variants. Assays for measuring serum concentrations of cTnT, as well as cTnI, have been reported for analyzing cardiac injury.

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