Anti-PPARγ Recombinant Rabbit

PPARγ (Peroxisome Proliferator-Activated Receptor Gamma) is a nuclear hormone receptor and a key regulator of metabolic processes. It is primarily expressed in adipose tissue, macrophages, and the colon, and it plays a central role in the regulation of glucose metabolism, lipid storage, and insulin sensitivity. PPARγ functions by binding to specific ligands, such as fatty acids and eicosanoids, and activating the transcription of target genes involved in adipocyte differentiation, lipid metabolism, and inflammation. It is crucial for maintaining energy balance and insulin sensitivity and has been implicated in the pathophysiology of metabolic disorders like type 2 diabetes and obesity. Additionally, PPARγ has anti-inflammatory effects and is a target for certain drugs, including thiazolidinediones, which are used to treat insulin resistance in diabetes.