Anti-Phospho-mTOR (Ser2448) Re

Phospho-mTOR (Ser2448) refers to the phosphorylation of the mammalian target of rapamycin (mTOR) at the serine 2448 residue. mTOR is a serine/threonine kinase that plays a central role in regulating cell growth, proliferation, metabolism, and survival. Phosphorylation at Ser2448 is mediated by the PI3K/Akt signaling pathway and is also influenced by downstream effectors such as p70 S6 kinase (S6K1), which can phosphorylate mTOR at this site in response to mitogenic and nutrient-derived stimuli. The phosphorylation of mTOR at Ser2448 serves as a marker for mTORC1 activation, linking extracellular signals to intracellular anabolic processes. However, it's important to note that while Ser2448 phosphorylation is associated with mTOR activity, it may not directly reflect mTOR kinase activity and could be part of a complex regulatory feedback loop. Due to its critical role in cellular functions and its dysregulation in diseases such as cancer, phospho-mTOR (Ser2448) is a significant focus in biomedical research and a potential target for therapeutic intervention.