Purified (azide-free) anti-β-A

Purified anti-β-Amyloid, 1-42 Antibody (Previously Covance catalog# SIG-39142)
12F4
Catalog# / Size 
805503 / 1 mL
Clone
Regulatory Status RUO
Other Names AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4,
protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral
vascular amyloid peptide, APP, Amyloid Precursor Protein
Previously Signet Catalog# 9142-02
Signet Catalog# 9142-05
Signet Catalog# 9142-10
Covance Catalog# SIG-39142
Isotype Mouse IgG1, κ
Description Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids in length that are crucially
involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of
Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by
certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as "seeds")
which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric
form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques
are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms
such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to
misfold.