- ￥1183
- BioLegend
- 329702
- 美国
- 2025年07月12日
- 免疫荧光，流式
- 小鼠
- Human Reported Reactivity African Green, Baboon, Cynomolgus, Rhesus
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- 技术资料
- 抗体名：
Purified anti-human CD274 (B7-H1, PD-L1)
- 抗体英文名：
Purified anti-human CD274 (B7-H1, PD-L1)
- 浓度：
0.5 mg/mL
- 应用范围：
免疫荧光，流式
- 宿主：
小鼠
- 供应商：
上海善然生物
- 库存：
现货
- 抗原来源：
小鼠
- 保质期：
2-3年左右
- 适应物种：
Human Reported Reactivity African Green, Baboon, Cynomolgus, Rhesus
- 标记物：
Purified
- 克隆性：
单克隆
- 保存条件：
2-8度
- 形态：
液体
- 规格：
100 μg
Purified anti-human CD274 (B7-H1, PD-L1) Antibody
29E.2A3
Catalog# / Size 329701 / 25 µg
329702 / 100 µg
Clone
Regulatory Status RUO
Other Names Programmed cell death ligand 1 (PD-L1), B7 homolog 1 (B7-H1)
Isotype Mouse IgG2b, κ
Description CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a
ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the
stimulatory and inhibitory signals needed for responses to microbes and maintenance of selftolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ
production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that
CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell
activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting
implications for its expression in a wide variety of cell types, including T and B cells, antigenpresenting cells, and nonhematopoietic cells.
Product Details
Verified Reactivity Human
Reported Reactivity African Green, Baboon, Cynomolgus, Rhesus
Antibody Type Monoclonal
Host Species Mouse
Immunogen Full length human PD-L1
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C.
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了 B7 家族的第三个成员 B7-H1（即日后的 PD-L1）[2]。2000 年，Tasuku Honjo 教授等人证明了 PD-L1 能与 PD-1 结合，进而抑制 T 细胞的增殖与细胞因子的分泌，负调控淋巴细胞的激活，从此，B7-H1 被正式命名为 PD-L1（陈列平教授则继续使用「B7-H1」命名）[3]。2003年，陈列平教授第一次成功地使用 PD-L1 封闭抗体联合 T 细胞回输技术治愈了约 60% 的头颈癌小鼠[4]。2014 年 12 月，首个应用于肿瘤治疗的抗 PD-1 抗体
Isolation of a Purified Epithelial Cell Population from Human Colon
. For the human colon, isolation techniques to allow direct study have been described for mononuclear cells in the lamina propria, smooth muscle cells at or below the muscularis mucosae, and cells of the enteric nervous system, located between the subserosa
，PD-1/PD-L1这么值钱，大家一定好奇它到底是什么鬼。 PD-1全名是程序性死亡分子1(programmed death-1)是Ishida等[1]通过消减杂交技术于1992年发现的[2]，是CD28家族成员，胞质区含有2个酪氨酸残基，1个位于靠近N端的免疫受体酪氨酸抑制基序(ITIM)中，另一个1个位于靠近C端的免疫受体酪氨酸转化基序(ITSM)中[2]。 PD-L1(CD274)是B7家族成员，是PD-1的配体，属于1型跨膜蛋白，全长290个氨基酸，包含1个IgV样
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