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- BioLegend
- 372734
- 美国
- 2025年08月12日
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
APC/Cyanine7 anti-human TIGIT (VSTM3)
- 抗体英文名：
APC/Cyanine7 anti-human TIGIT (VSTM3)
- 供应商：
上海善然生物科技有限公司
- 保存条件：
2-8℃
- 规格：
100tests
APC/Cyanine7 anti-human TIGIT (VSTM3) Antibody
A15153G
Catalog# / Size
372734 / 100 tests
Clone
Regulatory Status RUO
Other Names T-cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3, WUCAM
Isotype Mouse IgG2a, κ
Description T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM,
is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor)
family of immunoglobulin-like domain containing proteins. TIGIT is expressed on activated T
cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. TIGIT is a
negative regulator of NK and T cell activation. Expression of TIGIT is associated with
decreased functionality of CD8 T cells in chronic viral infection and tumors. TIGIT also
promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased
secretion of IL-10 and a diminished production of IL-12.
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文献和实验不只是 PD-1：CD96 正成为免疫治疗的下一个“必争之地”
研发阶段已推进至临床2期，部分在研管线列举如下表： 药物 靶点 药物类型 在研适应症 在研机构 最高研发阶段 Nelistotug CD96 单克隆抗体 非小细胞肺癌 | 晚期恶性实体瘤 | 肿瘤 GSK Plc | 23andMe, Inc. 临床2期 BMS-986442 CD96 x TIGIT 双特异性抗体 晚期癌症 | 局部晚期恶性实体瘤 | 胃癌 | 结肠癌 | 胃食管交界处腺癌 | 头颈部鳞状细胞癌 Agenus, Inc. | Bristol Myers
Fluorochrome Absorption and Emission Spectra
7 is a tandem conjugate system that combines APC and a cyanine dye (Cy7™) and has an absorption maximum of approximately 650 nm. When excited by light from a dye or HeNe laser, the excited fluorochrome (APC) is able to transfer its fluorescent energy
Fluorochrome Absorption and Emission
7 is a tandem conjugate system that combines APC and a cyanine dye (Cy7™) and has an absorption maximum of approximately 650 nm. When excited by light from a dye or HeNe laser, the excited fluorochrome (APC) is able to transfer its fluorescent energy
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