- ￥1868
- abinScience
- France
- MV001022
- 2026年03月03日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
- 保质期：
1 year
- 英文名：
Recombinant Mouse NLRP3 Protein, N-His-SUMO
- 库存：
999
- 供应商：
abinScience
- 规格：
100ug
| Product name | Recombinant Mouse NLRP3 Protein, N-His-SUMO |
|---|---|
| Catalog No. | MV001022 |
| Form | Lyophilized |
| Storage buffer | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Purity | >90% as determined by SDS-PAGE. |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Endotoxin level | Please contact with the lab for this information. |
| Expression system | E. coli |
| Accession | Q8R4B8 |
| Reconstitution | Reconstitute in sterile water for a stock solution. |
| Alternative Names | NACHT LRR and PYD domains-containing protein 3, EC:3.6.4.-, Cold autoinflammatory syndrome 1 protein homolog, Cryopyrin, Mast cell maturation-associated-inducible protein 1, PYRIN-containing APAF1-like protein 1, Nlrp3 |
| Species | Mus musculus (Mouse) |
| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
abinScience, founded in 2023 in Strasbourg, France, is committed to developing and producing high-quality life science reagents. Rooted in one of Europe’s leading hubs for scientific innovation, abinScience empowers global research through reliable, efficient experimental solutions. Guided by the vision of “Empowering Bioscience Discovery,” we support scientists worldwide in advancing the frontiers of bioscience.
Technology and Innovation
Relying on the global leading position in antibody and protein research and more than 20 years of industry experience of its parent company ProteoGenix since 2003...
Product categories and application fields.
Main products...
Application field: Infectious disease research, Neuroscience, Immunology, Oncology
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文献和实验• Molecular mechanisms regulating NLRP3 inflammasome activation., PMID:26549800
• NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation., PMID:38583156
• PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation., PMID:30487600
• NLRP3 inflammasome mediates M1 macrophage polarization and IL-1β production in inflammatory root resorption., PMID:31976565
• The NLRP3-inflammasome as a sensor of organelle dysfunction., PMID:33044555
• NLRP3 Inflammasome: A central player in renal pathologies and nephropathy., PMID:38857655
• The Role of the NLRP3 Inflammasome and Programmed Cell Death in Acute Liver Injury., PMID:36834481
• NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases., PMID:33673188
• NLRP3 and cancer: Pathogenesis and therapeutic opportunities., PMID:37866732
Immunity：厦门大学韩家淮团队揭示 PELO 控制 NOD 样受体家族蛋白寡聚化组装和激活的机制
。 研究者首先确认了 PELO 和 NLRP3 的直接相互作用，并发现这种相互作用是通过 NLRP3 的 NACHT 和 LRR 结构域介导的，不依赖于其 N 端的 PYD 结构域。由于 NACHT 和 LRR 是 NLR 家族蛋白的共有结构域，研究者进一步分析发现 PELO 可以特异性地和所有胞质内的 NLR 家族蛋白相互作用。接着，研究者在多种细胞和小鼠模型中证实 PELO 参与调控 NLR 家族蛋白介导的天然免疫应答反应，如 NOD2 介导的 NF-κB 和 MAPK 信号通路激活，NLRP3
科研人必看：多肽、蛋白质、重组蛋白分不清？ 应用场景有哪些？定制如何选？
动物细胞表达：最接近天然状态的表达平台，提供完整的人源化翻译后修饰 (如糖基化、磷酸化)，适合重组抗体、细胞因子等需要复杂修饰的蛋白。 昆虫细胞表达：基因承载容量大，支持大分子量蛋白和激酶的表达。 『多种融合标签』 标签的选择直接影响纯化效率和下游应用，MCE 支持多种融合标签，可根据实验需求灵活搭配。 常规纯化标签：His 标签 (镍柱纯化，分子量小)、GST 标签 (Glutathione 亲和纯化，兼具促溶作用)、Fc 标签 (Protein A/G 亲和纯化，适合免疫相关实验)、Flag 标签
炎症促发阿尔茨海默病又添一力证！NLRP3 炎症小体激活引发 tau 蛋白异常
的经典结构，即核心部分 NLRP3，包括 N 端热蛋白结构域（pyrin domain，PYD)，介导同型蛋白相互作用，参与炎症小体激活信号转导过程；C 端的亮氨酸富集结构域（leucine-rich repeat，LRR），可识别 PAMP 及 DAMP；中央为核苷酸寡聚化结构域（nucleoside triphosphatase domain，NACTH），对核酸连接、蛋白寡聚化及炎症小体复合物的形成发挥着重要作用。NLRP3 炎症小体作为固有免疫的重要组分在机体免疫反应和疾病发生过程中均发挥
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