- ￥1868
- abinScience
- France
- HB522012
- 2026年03月03日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
- 保质期：
1 year
- 英文名：
Recombinant Human DCAF15 Protein, N-His
- 库存：
999
- 供应商：
abinScience
- 规格：
100ug
| Product name | Recombinant Human DCAF15 Protein, N-His |
|---|---|
| Catalog No. | HB522012 |
| Form | Lyophilized |
| Storage buffer | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Purity | >90% as determined by SDS-PAGE. |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Endotoxin level | Please contact with the lab for this information. |
| Expression system | E. coli |
| Accession | Q66K64 |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Alternative Names | DDB1- and CUL4-associated factor 15; DCAF15; C19orf72 |
| Species | Homo sapiens (Human) |
| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
abinScience, founded in 2023 in Strasbourg, France, is committed to developing and producing high-quality life science reagents. Rooted in one of Europe’s leading hubs for scientific innovation, abinScience empowers global research through reliable, efficient experimental solutions. Guided by the vision of “Empowering Bioscience Discovery,” we support scientists worldwide in advancing the frontiers of bioscience.
Technology and Innovation
Relying on the global leading position in antibody and protein research and more than 20 years of industry experience of its parent company ProteoGenix since 2003...
Product categories and application fields.
Main products...
Application field: Infectious disease research, Neuroscience, Immunology, Oncology
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文献和实验• Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15., PMID:28302793
• Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy., PMID:32200025
• RNA-binding motif protein 39 (RBM39): An emerging cancer target., PMID:33238031
• Developments of CRBN-based PROTACs as potential therapeutic agents., PMID:34411892
• Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma., PMID:33833131
• Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia., PMID:30799057
• Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15., PMID:31686031
• Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39., PMID:37666821
• Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15., PMID:31693891
1 月内连登 4 顶刊，这个炙手可热的明星蛋白 GDF15 到底什么来路？
关于 GDF15 的论文，也就是我们一开始提到的这两篇。在西北太平洋国家实验室的 Thomas O. Metz 课题组题为《Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention》的文章中，他们利用蛋白质组学分析从人类胰岛中发现了 GDF15 对一型糖尿病的影响。研究发现了 GDF15 帮助胰岛 beta 细胞抵抗压力导致
15 秒止血！MIT 赵选贺团队受自然启发，研制出如此神奇的
by barnacle glue. Nat Biomed Eng (2021).2. Sharma, B. et al. Human cartilage repair with a photoreactive adhesive–hydrogel composite. Sci. Transl. Med. 5, 167ra6 (2013).3. Annabi, N. et al. Engineering a highly elastic human protein-based sealant for surgical
Recombinant DNA Engineering, Or Cloning Genes In Plasmids
and thus fusion proteins. For example there might be sequence for a fluorescent protein such as GFP or a peptide tag such as HA upstream of MCS (and downstream of promoter) so that an insert in frame will lead to the generation of a fusion protein, an N-terminal
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