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- Solarbio
- 北京
- P01152
- 2026年08月13日
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- 文献和实验
- 技术资料
- 保质期：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 保存条件：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 英文名：
NRG1Beta
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ¥988.00 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ¥2600.00 |
| 规格： | 500ug | 产品价格： | ¥14784.00 |
| 规格： | 1mg | 产品价格： | ¥21120.00 |
| 基因名 | NRG1Beta |
| 别名 | Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1; EGF; NRG1; GGF; HGL; HRGA; NDF; SMDF; Heregulinβ-1 |
| 蛋白号 | AAA58639.1 |
| 种属 | Human |
| 宿主 | E.coli |
| 产品描述 | Recombinant Human Neuregulin-1 Beta is produced by our E.coli expression system and the target gene encoding Ser2-Lys246 is expressed. |
| 区间范围 | Ser2-Lys246 |
| 标签信息 | Tag free |
| 预测分子量 | 34 kDa |
| 表观分子量 | 34 KDa, reducing conditions |
| 纯度 | ≥85% by SDS-PAGE. |
| 内毒素 | <0.01EU/ug as determined by LAL test. |
| 溶剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Reconstituted protein solution can be diluted with distilled water. Always centrifuge tubes before opening. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: 2-8°C for 2-7 days under sterile conditions after redissolves; -20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; -20°C to -70℃ for 12 months in lyophilized state. |
| 运输条件 | 冷冻运输 |
| 背景说明 | Pro-neuregulin-1, Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. |
| 细胞活性 | Human breast cancer organoids were cultured with Wnt3a, Noggin, R-spondin3, KGF, FGF-10, EGF and NRG1-beta 1. DAPI (blue), Ki67(red) and ER(green). |
| ELISA活性 | No activity experimental data, to be verified. |
| SPR/BLI活性 | No activity experimental data, to be verified. |
| 研究领域 | 生物制药相关研究 |
| 英文名称 | NRG1Beta |
| 中文名称 | NRG1Beta蛋白 |
| 单位 | 支 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
答：您好，本品理论分子量为26.9 KDa，表观分子量为34 KDa。
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从罕见病到“不限癌种”，NRG1靶点凭什么一年内连斩三大适应症？
（如PROTAC、ADC）的研发也将迎来新一轮热潮。 NRG1蛋白 Recombinant Human Pro-neuregulin-1, membrane-bound isoform(NRG1),partial (Active) (Code: CSB-MP016077HU1(F6)) 参考文献： [1] Gay, Nathan D., et al. "Durable response to afatinib in lung adenocarcinoma harboring NRG1 gene
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