- ￥988 - 21120
- Solarbio
- P01151
- 北京
- 2025年07月25日
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- 详细信息
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥988.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Protein S100-A12;Calcium-binding protein in amniotic fluid 1;Calgranulin-C;Extracellular newly identified RAGE-binding protein;Migration inhibitory factor-related protein 6;S100 calcium-binding protein A12;Calcitermin;S100A12;CGRP;MRP-6;EN-RAGE |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | There are at least 21 different S100 proteins and the protein is 100% soluble in ammonium sulfate at neutral pH.S100 proteins play a role in regulation of protein phosphorylation，transcription factors，the dynamics of cytoskeleton constituents，enzyme activities，cell growth and differentiation，and the inflammatory response.S100A12 is characterized by two EF-hand calcium-binding motifs，zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes，promotion of cytokine and chemokine production，and regulation of leukocyte adhesion and migration.EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER).Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1.It also acts as a monocyte and mast cell chemoattractant.Moreover，it can stimulate mast cell degranulation and activation which generates chemokines，histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation.It can inhibit the activity of matrix metalloproteinases; MMP2，MMP3 and MMP9 by chelating Zn2+ from their active sites. |
| 来源 | E.coli |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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P01151 Recombinant Human S100A12/Protein S100-A12/EN-RAGE 细胞因子/蛋白
￥988 - 21120
