Recombinant Human SIRPA (C-mIgG2aFc)产品图

Recombinant Human SIRPA (C-mIg

G2aFc)
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  • ¥988 - 21120
  • Solarbio已认证
  • 北京
  • P01119
  • 2026年08月13日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保质期

      Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.

    • 保存条件

      Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.

    • 英文名

      SIRPA

    • 库存

      999

    • 供应商

      北京索莱宝科技有限公司

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥988.00
    规格:50ug产品价格:¥2600.00
    规格:500ug产品价格:¥14784.00
    规格:1mg产品价格:¥21120.00
    基因名SIRPA
    别名Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; Signal-regulatory protein alpha-1; p84; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP
    蛋白号CAA71403.1
    种属Human
    宿主HEK293
    产品描述Recombinant Human Signal-Regulatory Protein Alpha-1 is produced by our Mammalian expression system and the target gene encoding Glu31-Arg370 is expressed with a mouse IgG2a Fc tag at the C-terminus.
    区间范围Glu31-Arg370
    标签信息C-mIgG2aFc
    预测分子量80-120 kDa
    表观分子量80-120 KDa, reducing conditions
    纯度≥95% by SDS‐PAGE.
    内毒素<1EU/ug as determined by LAL test.
    溶剂Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, pH 7.4.
    复溶Reconstituted protein solution can be diluted with distilled water. Always centrifuge tubes before opening. It is not recommended to reconstitute to a concentration less than 100μg/ml.
    储存条件Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at:
    2-8°C for 2-7 days under sterile conditions after redissolves;
    -20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves;
    -20°C to -70℃ for 12 months in lyophilized state.
    运输条件冷冻运输
    背景说明Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
    细胞活性No activity experimental data, to be verified.
    ELISA活性No activity experimental data, to be verified.
    SPR/BLI活性Loaded Anti-Human SIRPA mAb-Fc on AHC Biosensor, can bind Human SIRPA-mIgG2aFc with an affinity constant of 0.14 nM as determined in BLI assay.
    研究领域生物制药相关研究
    英文名称SIRPA
    中文名称SIRPA蛋白
    单位
    规格10ug ; 50ug ; 500ug ; 1mg

    产品细节图片1
    Bioactivity-SPR/BLI

    产品细节图片2
    Purity-SDS-PAGE

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