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- 北京
- 2025年07月25日
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- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥988.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | B7 homolog 2;B7-H2;B7-like protein Gl50;B7RP-1LICOS;CD275;CD275 antigen;ICOS ligand;ICOSL;ICOS-L;inducible T-cell co-stimulator ligand;B7RP-1;CD275;GL50;ICOSL;ICOSLG;B7H2;B7RP1 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Mouse ICOS ligand(B7-H2) is an approximately transmembrane glycoprotein in the B7 family of immune regulatory molecules.B7-H2 is expressed on antigen presenting cells such as B cells，macrophages，monocytes，and dendritic cells.It binds to ICOS on activated T cells，leading to both positive and negative effects on immune responses including its own down-regulation.The B7-H2 interaction with ICOS is costimulatory for T cell proliferation as well as the development of B cells，plasma cells，follicular helper T cells and germinal centers.B7-H2 contributes to the development of allergic asthma by enhancing Th2 biased immune responses，limiting Th17 responses，and promoting eosinophilic infiltration into the lung.Its activation of ICOS on Treg limits pulmonary inflammation and airway hyperresponsiveness，promotes the development of inhalational tolerance，and impairs antitumor immunity.In the thyroid，B7-H2 is up-regulated on thyrocytes during inflammation and promotes their proliferation and production of thryoid hormones. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验，IL-10则下调PBMC中树突状细胞CD86的表达。CD80／CD86皆通过其胞膜外区V样结构域结合受体CD28和CDl52(CTLA-4)。功能参见CD28／CDl25部分。 B7家族的其他成员 B细胞和APC上除表达B7―1(CDS0)和137-2(CD86)以外，还有几种B7家族新的成员。 ①ICOS-L，即B7-H2(CD275)，与]37-1和B7-2约有20％同源性。ICOS―l在淋巴滤泡中的B细胞表达水平最高，ICOS―L
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