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- Solarbio
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- 北京
- 2025年07月25日
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- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2288.0 |
| 规格： | 10ug | 产品价格： | ￥832.0 |
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:TEAD1-Mediated Trans-Differentiation of Vascular Smooth Muscle Cells into Fibroblast-Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques
成员:Ming Zhai, Zhijun Lei, Yefei Shi, Jiayun Shi, Yanxi Zeng, Shiyu Gong, Weixia Jian, Jianhui Zhuang, Qing Yu, Mark W. Feinberg, Wenhui Peng
论文因子:14.3 发表期刊:Advanced Science pmid:39665254
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis
成员:Zhai Ming, Gong Shiyu, Luan Peipei, Shi Yefei, Kou Wenxin, Zeng Yanxi, Shi Jiayun, Yu Guanye, Hou Jiayun, Yu Qing, Jian Weixia, Zhuang Jianhui, Feinberg Mark W., Peng Wenhui
论文因子:17.694 发表期刊:Nature Communications pmid:36473863
| 基本信息 | |
| 基因名 | |
| 别名 | Oxidized Low-Density Lipoprotein Receptor 1;Ox-LDL Receptor 1;C-Type Lectin Domain Family 8 Member A;Lectin-Like Oxidized LDL Receptor 1;LOX-1;Lectin-Like oxLDL Receptor 1;hLOX-1;Lectin-Type Oxidized LDL Receptor 1;OLR1;CLEC8A;LOX1 |
| 中文名称 | Recombinant Human LOX-1/OLR1 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted，single-pass type II membrane protein which belongs to the C-type lectin superfamily.Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta，lung，liver，brain，aortic intima，bone marrow，spinal cord and substantia nigra.The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF，IFNG and IL6 by pathological conditions，such as hyperlipidemia，hypertension and diabetes mellitus.Ox-LDL Receptor 1 mediates the recognition，internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells.Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release，monocyte adhesion and apoptosis.Ox-LDL Receptor 1 also binds to oxLDL，which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells，thereby participating in cell-mediated antigen cross-presentation.It also participates in inflammatory process，by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:TEAD1-Mediated Trans-Differentiation of Vascular Smooth Muscle Cells into Fibroblast-Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques
成员:Ming Zhai, Zhijun Lei, Yefei Shi, Jiayun Shi, Yanxi Zeng, Shiyu Gong, Weixia Jian, Jianhui Zhuang, Qing Yu, Mark W. Feinberg, Wenhui Peng
论文因子:14.3 发表期刊:Advanced Science pmid:39665254
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis
成员:Zhai Ming, Gong Shiyu, Luan Peipei, Shi Yefei, Kou Wenxin, Zeng Yanxi, Shi Jiayun, Yu Guanye, Hou Jiayun, Yu Qing, Jian Weixia, Zhuang Jianhui, Feinberg Mark W., Peng Wenhui
论文因子:17.694 发表期刊:Nature Communications pmid:36473863
OLR1（LOX-1）配体结合机制、胞内信号调控及蛋白试剂应用解析
疗效与安全性，为OLR1靶向治疗在心血管疾病领域的应用提供临床依据。菲恩生物提供高纯度、高活性的 OLR1 重组蛋白，助力动脉粥样硬化与炎症信号通路机制研究、氧化低密度脂蛋白（ox-LDL）介导的血管损伤解析，以及靶向 OLR1 通路的诊断试剂与治疗药物的开发与筛选。 以下是菲恩生物OLR1相关指标重组蛋白产品推荐 重组蛋白 货号 产品名称 表达宿主 预测分子量 Pr22747 Recombinant Human OLR1 Mammalian Cells 30-35 kDa
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