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- 详细信息
- 文献和实验
- 技术资料
- 库存:
现询
- 供应商:
北京索莱宝科技有限公司
- 规格:
1mg/500ug/50ug/10ug
| 规格: | 1mg | 产品价格: | ¥28800.0 |
|---|---|---|---|
| 规格: | 500ug | 产品价格: | ¥19200.0 |
| 规格: | 50ug | 产品价格: | ¥2730.0 |
| 规格: | 10ug | 产品价格: | ¥910.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Lymphocyte Activating 3;LAG3;LAG-3;CD223 |
| 中文名称 | Recombinant Cynomolgus LAG-3/CD223/Lymphocyte activation gene 3 Protein |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS,PH7.4. |
| 纯度 | ≥90% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Lymphocyte Activating 3(LAG3) belongs to immunoglobulin (Ig) superfamily,Macaca fascicularis LAG3 cDNA encodes 533 amino acids (aa) that include a 17 aa signal sequence,a 451 aa extracellular domain (ECD) with two Ig-like domains,a transmembrane region and a highly charged cytoplasmic region.LAG3's main ligand is MHC class II,to which it binds with higher affinity than CD4.The protein negatively regulates cellular proliferation,activation,and homeostasis of T cells,in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/μg(1 EU/μg). |
| 单位 | 支 |
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文献和实验after specifically interacting with its receptors. Human IL-2 is a 133-amino acid polypeptide with a molecular mass of 15-18 kDa. IL-2 signaling is mediated by a multichain receptor complex consisting of an alpha (CD25), beta (CD122), and gamma (CD132) chain. The IL
after specifically interacting with its receptors. Human IL-2 is a 133-amino acid polypeptide with a molecular mass of 15-18 kDa. IL-2 signaling is mediated by a multichain receptor complex consisting of an alpha (CD25), beta (CD122), and gamma (CD132) chain. The IL
, the majority of which participate in the host immune response [1] including immunoglobulin (Ig) gene rearrangements [2,3] . Various types of stimuli (cytokines, CD40 ligation, TLR ligation, stress factors, microbial pathogens, etc.) activate and phosphorylate
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