P00701 Recombinant Mouse Trans
ferrin R/TfR/Transferrin receptor protein 1/CD71/TfR1/TR 细胞因子/蛋白- ￥780 - 11520
- Solarbio
- P00701
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥11520.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥8064.0 |
| 规格： | 50ug | 产品价格： | ￥1820.0 |
| 规格： | 10ug | 产品价格： | ￥780.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Transferrin receptor protein 1;TR;TfR;TfR1;Trfr;CD71;Tfrc |
| 中文名称 | Recombinant Mouse Transferrin R/TfR/Transferrin receptor protein 1/CD71/TfR1/TR |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa).TFRC regulated by cellular iron levels through binding of the iron regulatory proteins，IRP1 and IRP2，to iron-responsive elements in the 3'-UTR.It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen，DR1.It Interacts with SH3BP3 and STEAP3，facilitates TFRC endocytosis in erythroid precursor cells.Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes.Endosomal acidification leads to iron release.The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.Transferrin receptor is necessary for development of erythrocytes and the nervous system.A second ligand，the heditary hemochromatosis protein HFE，competes for binding with transferrin for an overlapping C-terminal binding site.It positively regulates T and B cell proliferation through iron uptake. |
| 来源 | Human Cells |
| 溶剂 | Dissolve the lyophilized protein in distilled water. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Mouse Strains and Genetic Nomenclature
. Biol. J. Linnean Soc. 30:51‐58. Bulfield, G., Siller, W.G., Wight, P.A., and Moore, K.J. 1984. X chromosome‐linked muscular dystrophy (mdx) in the mouse. Proc. Natl. Acad
Capture and Qualitative Analysis of the Activated Fc Receptor Complex from Live Cells
Bajno, L., Peng, X.R., Schreiber, A.D., Moore, H.P., Trimble, W.S., and Grinstein, S. 2000. Focal exocytosis of VAMP3‐containing vesicles at sites of phagosome formation. J. Cell Biol. 149:697‐706.
The Mouse as Model System to Study Host‐Pathogen Interactions in Influenza A Infections
Maines, T.R., Lu, X.H., Erb, S.M., Edwards, L., Guarner, J., Greer, P.W., Nguyen, D.C., Szretter, K.J., Chen, L.M., Thawatsupha, P., Chittaganpitch, M., Waicharoen, S., Nguyen, D.T., Nguyen, T., Nguyen, H.H., Kim, J.H., Hoang, L.T., Kang, C
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