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- 文献和实验
- 技术资料
- 保质期：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 保存条件：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 英文名：
TfR
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ¥780.00 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ¥1820.00 |
| 规格： | 500ug | 产品价格： | ¥8064.00 |
| 规格： | 1mg | 产品价格： | ¥11520.00 |
| 基因名 | TfR |
| 别名 | Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; CD71; Tfrc |
| 蛋白号 | Q62351 |
| 种属 | Mouse |
| 宿主 | HEK293 |
| 产品描述 | Recombinant Mouse Transferrin Receptor Protein 1 is produced by our Mammalian expression system and the target gene encoding Cys89-Phe763 is expressed with a 8His tag at the N-terminus. |
| 区间范围 | Cys89-Phe763 |
| 标签信息 | N-8His |
| 预测分子量 | 90 kDa |
| 表观分子量 | 90 KDa, reducing conditions |
| 纯度 | ≥95% by SDS‐PAGE. |
| 内毒素 | <1EU/ug as determined by LAL test. |
| 溶剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 5% Trehalose, 5% Mannitol, 0.01% tween80, pH 7.4. |
| 复溶 | Reconstituted protein solution can be diluted with distilled water. Always centrifuge tubes before opening. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: 2-8°C for 2-7 days under sterile conditions after redissolves; -20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; -20°C to -70℃ for 12 months in lyophilized state. |
| 运输条件 | 冷冻运输 |
| 背景说明 | Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa). TFRC regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3’-UTR. It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen, DR1. It Interacts with SH3BP3 and STEAP3, facilitates TFRC endocytosis in erythroid precursor cells. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. It positively regulates T and B cell proliferation through iron uptake. |
| 细胞活性 | No activity experimental data, to be verified. |
| ELISA活性 | No activity experimental data, to be verified. |
| SPR/BLI活性 | No activity experimental data, to be verified. |
| 研究领域 | 生物制药相关研究 |
| 英文名称 | TfR |
| 中文名称 | TfR蛋白 |
| 单位 | 支 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
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Nature重磅技术TransTAC选中的受体！TFR1这个铁转运蛋白要火了
，已用于CAR-T活性调控；CD24-H7双特异性降解剂通过TFR1介导CD24溶酶体降解增强抗肿瘤免疫。在铁死亡治疗方面，TFR1高表达肿瘤对铁死亡诱导剂敏感性增强，青-蒿-素通过TFRC-HSPA9轴选择性诱导胃癌铁死亡。总体而言，TFR1在PDC、双抗、蛋白降解和铁死亡诱导等方向均展现临床转化前景，未来需在靶向特异性、安全性和联合免疫治疗策略方面深入探索。 5. 华美生物TFR1相关产品 ● TFR1重组蛋白 Recombinant Human Transferrin receptor
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