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- Solarbio
- P00465
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥6448.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥4524.0 |
| 规格： | 50ug | 产品价格： | ￥1456.0 |
| 规格： | 10ug | 产品价格： | ￥520.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Programmed cell death 1 ligand 2;Pdcd1lg2;PD-1 ligand 2;PD-L2;PDCD1 ligand 2;B7-DC;CD273; |
| 中文名称 | Recombinant Mouse PD-L2/B7-DC/CD273/Programmed cell death ligand 2 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Programmed cell death 1 ligand 2 (PD-L2)，also known as butyrophilin B7-DC or PDCD1 ligand 2，belongs to the member of B7 family which can regulate the activation and tolerance ofT cells.PD-L2 is one ligand for Programmed cell death 1(PD-1)，and the other is PD-L1.These two ligands shares 34% aa sequence identity.Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide，a 201 aa extracellular region，a 21 aa transmembrane domain and a 32 aa cytoplasmic region.The mouse PD-L2 gene is highly expressed in heart，placenta，pancreas，lung and liver while expressed weakly in spleen，lymph nodes and thymus.Besides，the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment，and up-regulated by IFNG/IFN-gamma stimulation in monocytes.PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production.Recent studies demonstrate that the expression of PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells，at both the induction and effector phase of antitumor immunity.Moreover，PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Staining Methods for cell death
2 mg/ml P. I. 6 ul 5 mg/ml FDA R. T. 3 min Rinse 1 X PBS leave cells in PBS. Examine cells under the scope immediately. Note: If the P.I. staining is not strong enough to be picked up easily
Immunohistological Tools to Discriminate Apoptotic and Necrotic Cell Death in the Skin
programmed necrosis also termed necroptosis in human skin remains poorly understood. We have recently described a mouse model of skin inflammation dependent on necroptotic cell death. Here we describe an immunohistological protocol allowing
Staining Methods for cell death Z. Xia 10/2/95
. I. 6 ul 5 mg/ml FDA R. T. 3 min Rinse 1 X PBS leave cells in PBS. Examine cells under the scope immediately. Note: If the P.I. staining is not strong enough to be picked up easily under your scope, use 2 X P. I., i.e
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