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- 详细信息
- 文献和实验
- 技术资料
- 库存:
现询
- 供应商:
北京索莱宝科技有限公司
- 规格:
1mg/500ug/50ug/10ug
| 规格: | 1mg | 产品价格: | ¥29280.0 |
|---|---|---|---|
| 规格: | 500ug | 产品价格: | ¥18300.0 |
| 规格: | 50ug | 产品价格: | ¥1872.0 |
| 规格: | 10ug | 产品价格: | ¥780.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Programmed cell death protein 1;PDCD1;PD-1;hPD-1;CD279 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain.PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators.PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1,IL-4,IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.In addition,coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer.PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance,and thus contributes to the prevention of autoimmune diseases.As a cell surface molecule,PDCD1 regulates the adaptive immune response.Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation,cytokine production,and cytolytic function. |
| 来源 | Human cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test. |
| 单位 | 支 |
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