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P00210 Recombinant Mouse Inter

leukin-23 Receptor/IL-23R 细胞因子/蛋白
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  • ¥988 - 21120
  • Solarbio已认证
  • P00210
  • 北京
  • 2025年07月25日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现询

    • 供应商

      北京索莱宝科技有限公司

    • 规格

      1mg/500ug/50ug/10ug

    规格:1mg产品价格:¥21120.0
    规格:500ug产品价格:¥14784.0
    规格:50ug产品价格:¥2600.0
    规格:10ug产品价格:¥988.0
    Recombinant Mouse Interleukin-23 Receptor is produced by our Mammalian expression system and the target gene encoding Gly24-Asp372 is expressed with a Fc tag at the C-terminus.
    基本信息
    基因名
    别名Interleukin-23 receptor;Il23r;IL-23 receptor;IL-23R;interleukin 23 receptor
    外观(性状)Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    纯度≥95% as determined by reducing SDS-PAGE.
    储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    运输条件The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
    背景说明Interleukin 23 receptor (IL23R),a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2,is a type I cytokine receptor for IL23.IL23R is comprised of two subunits,the IL12Rβ1 subunit,which is shared with several cytokines,and a subunit that is unique to IL-23.IL23,after binding to IL23R,activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes.IL23R is expressed on T cells,NK cells,dendritic cells,and macrophages.In fact,polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis,multiple sclerosis,Graves's ophtalmopathy and inflammatory bowel diseases.The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
    来源Human Cells
    溶剂Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
    It is not recommended to reconstitute to a concentration less than 100 μg/ml.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    内毒素Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.
    单位

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    • Mouse Strains and Genetic Nomenclature

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      的炎症小体(Inflammasome),NOD2 等形成的 Nodosome,从而激活 NF-κB 通路、MAPK 通路、细胞焦亡等,释放 TNFα,IL-1β 和 IL-18 等炎性细胞因子,介导下游一系列免疫炎症级联反应【1,2】。这是机体最为基本的天然免疫防御反应之一,在机体清除病原感染和内源危险信号中发挥至关重要的作用。在人体中,多个 NLR 基因突变导致的异常激活也被发现参与了脓毒症、炎性肠病等多种重大炎性疾病的病理进程。 NLR 家族蛋白在结构上都含有一个核苷酸结合寡聚化结构域  

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    ¥988 - 21120