- ￥260 - 6240
- Solarbio
- P00200
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥6240.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥4680.0 |
| 规格： | 50ug | 产品价格： | ￥728.0 |
| 规格： | 10ug | 产品价格： | ￥260.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | CD119;Interferon gamma receptor 1;IFNGR1;IFN-gamma receptor 1;IFN-gamma-R1;CD119 antigen;IFN gamma receptor 1;IFNGR;immune interferon receptor 1;interferon gamma receptor 1;interferon-gamma receptor alpha chain |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | The tetrameric receptor complex for IFNγ consists of two subunits，IFNGR1 (IFNγ Rα) and IFNGR2 (IFNγ Rβ)，through which the dimeric IFN-γ exerts its biological functions，including antiviral，antiproliferation and immune-modulatory activity in mammals.Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family.FNGR1，widely expressed in most host cells，is essential for IFNγ binding，receptor trafficking，and signal transduction.IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site，a signal transducer and activator of transcription 1 (STAT1) binding site.The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs). |
| 来源 | Human cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验可能存在着第二条链。 IFN-γR为穿膜糖蛋白，胞膜外区、穿膜外区、穿膜区和胞浆区分别有228、21和223个氨基酸残基，从胞膜外区结构特征来看，属于细胞因子受体干扰素受体家族，最近命名为CDw119。 IFN-γ配体诱导IFN-γR二聚体化在信号转导中可能起重要作用，并与受人本的磷酸化有关。IFN-γ与受体结合后可活化多种IFN-γ调节的基因。目前已知，IFN-γ刺激后至少有20种蛋白被表达，其中12种是IFN刺激后所特有的。这种表达是由于活化特异的DNA结合蛋白使其从胞浆
4:1 rat-mouse 5:1 T cell fusion 1:1 Fusion Protocol: 1. Aspirate all supernatant and suspend pellet
General Fusion Protocol Materials: P3X63Ag8.653 murine myeloma or YB2/0 (maintained at 6 /ml) 50% w/v PEG 1500, warmed to 37° C Medium: IMDM supplemented with 20% fetal bovine serum, 4 mM L-
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