- ￥520 - 6448
- Solarbio
- P00194
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥6448.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥4524.0 |
| 规格： | 50ug | 产品价格： | ￥1456.0 |
| 规格： | 10ug | 产品价格： | ￥520.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Programmed cell death protein 1;PD-1;CD279;Pdcd1;mPD-1 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Programmed Death-1 (PD-1)，firstly cloned from mouse T cell hybridoma 2B4.11，is one member of CD28/CTLA-4 superfamily.PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule.This family also include members of CD28，CTLA-4 and ICOS.The mouse Programmed Death-1 protein，encoded by PD-1 gene，comprises four parts including a putative 20 aa signal peptide，a 149 aa extracellular region，a 21 aa transmembrane domain and a 98 aa cytoplasmic region.The cytoplamsic tail of PD-1 contains two structural motifs，an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating.Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1.Recently，programmed death-1 (PD-1) with its ligands，programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2)，was found to regulate T-cell activation and tolerance，upon ligand binding，inhibiting T-cell effector functions in an antigen-specific manner.PD-1 gene knocked out mice would induce some autoimmune diseases，which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance.Thus，PD-1 may be a useful target for the immunologic therapy of carcinoma，infection，autoimmune diseases as well as organ transplantation. |
| 来源 | Human cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test. |
| 单位 | 支 |
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