- ￥312 - 6240
- Solarbio
- P00381
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥6240.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥4732.0 |
| 规格： | 50ug | 产品价格： | ￥936.0 |
| 规格： | 10ug | 产品价格： | ￥312.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Ig gamma-3 chain C region;IgG3 Fc |
| 中文名称 | Recombinant Mouse IgG3 Fc/Ig gamma-3 chain C region |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta，Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells，and constitutes 75% of serum immunoglobulins in humans.IgG antibodies protect the body against the pathogens by agglutination and immobilization，complement activation，toxin neutralization，as well as the antibody-dependent cell-mediated cytotoxicity (ADCC).IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds，that is the two identical halves form the Y-like shape.IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment (crystallizable fragment).IgG1 is most abundant in serum among the four IgG subclasses (IgG1，2，3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity.Fc fragment is demonstrated to mediate phagocytosis，trigger inflammation，and target Ig to particular tissues.Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs，and has numerous applications in biotechnology as a reagent for affinity purification.Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验E L I S A w i t h p l a t e l e t s
prepare platelets from control and immunized mice distribute 2.5 x106 platelets per well on F-bottomed MaxiSorp Nunc-Immuno microplates (GibcoBRL, Roskilde, Denmark), centrifuge at 3000 rpm, 7 min, 10ѓC. fix with PBS-PF
，亲合力增高Kd为10-8M。IgG与Clq结合点位于CH2功能区中最后一个β折叠股318～322位氨基酸残基(Glu-x-Lys-x-Lys)。IgM倍以上。人类天然的抗A和抗B血型抗体为IgM，血型不符合引韦的输血反应发生快而且严重。 2.凝聚的IgA、IgG4和IgE等可通过替代途径活化补体。 (三)结合Fc受体 不同细胞表面具有不同Ig的Fc受体，分别用FcγR、FcεR、FcαR等来表示。当Ig与相应抗原
Mouse Strains and Genetic Nomenclature
Bishop, C.E., Boursot, P., Baron, B., Bonhomme, F., and Hatat, D. 1985. Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musculus Y chromosome. Nature 315:70‐72
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