P01106 Recombinant Mouse TIGIT
/VSIG9/VSTM3/T-cell immunoreceptor with Ig and ITIM domains 细胞因子/蛋白- ￥988 - 21120
- Solarbio
- P01106
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥988.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | T-cell immunoreceptor with Ig and ITIM domains;Tigit |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | T cell immunoreceptor with Ig and ITIM domains (TIGIT)，also called WUCAM，VSIG9 and Vstm3，is a member of the CD28 family within the Ig superfamily of proteins.TIGIT contains an immunoglobulin variable domain，a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM)，and is expressed on regulatory，memory，activated T cells and NK cells.TIGIT binds to CD155(PVR) that appear on dendritic cells (DC)，macrophages and endothelium with high affinity，and CD112(PVRL2) with lower affinity，but not CD113 (PVRL3).TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10，but inhibit the macrophage activation.Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges，while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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