- ￥468 - 8160
- Solarbio
- P00162
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥8160.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥6188.0 |
| 规格： | 50ug | 产品价格： | ￥1092.0 |
| 规格： | 10ug | 产品价格： | ￥468.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Tumor Necrosis Factor;Cachectin;TNF-Alpha;Tumor Necrosis Factor Ligand Superfamily Member 2;TNF-a;TNF;TNFA;TNFSF2 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB，150mM NaCl,pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages，monocytes，neutrophils，T-cells，and NK-cells following stimulation by bacterial LPS.Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete little or no TNF-α.Synthesis of TNF-α can be induced by many different stimuli including interferons，IL2，and GM-CSF.The clinical use of the potent anti-tumor activity of TNF-α has been limited by the proinflammatory side effects such as fever，dose-limiting hypotension，hepatotoxicity，intravascular thrombosis，and hemorrhage.Designing clinically applicable TNF-α mutants with low systemic toxicity has been of intense pharmacological interest.Human TNF-α that binds to murine TNF-R55 but not murine TNF-R7，exhibits retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF-α，which binds to both murine TNF receptors.Based on these results，many TNF-α mutants that selectively bind to TNF-R55 have been designed.These mutants displayed cytotoxic activities on tumor cell lines in vitro and have exhibited lower systemic toxicity in vivo.Recombinant Human TNF-α High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8，Lys9，Arg10 and Phe157.This mutant form has been shown to have increased activity with less inflammatory side effects in vivo. |
| 来源 | E.coli |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test. |
| 单位 | 支 |
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