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P00064 Recombinant Human IL-3

3 细胞因子/蛋白
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  • ¥1560 - 29280
  • Solarbio已认证
  • P00064
  • 北京
  • 2025年07月25日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现询

    • 供应商

      北京索莱宝科技有限公司

    • 规格

      1mg/500ug/50ug/10ug

    规格:1mg产品价格:¥29280.0
    规格:500ug产品价格:¥18300.0
    规格:50ug产品价格:¥4576.0
    规格:10ug产品价格:¥1560.0
    Recombinant Human Interleukin-33 is produced by our E.coli expression system and the target gene encoding Ser112-Thr270 is expressed.
    基本信息
    基因名
    别名Interleukin-33;IL-33;Interleukin-1 Family Member 11;IL-1F11;Nuclear Factor From High Endothelial Venules;NF-HEV;IL33;C9orf26;IL1F11;NFHEV
    外观(性状)Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
    纯度≥95% as determined by reducing SDS-PAGE.
    储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    运输条件The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
    背景说明Interleukin-33 (IL-33) was initially discovered as a nuclear factor NF-HEV abundantly expressed in high endothelial venules.It is a 30-32 kD pro-inflammatory protein with intracellular and extracellular activities and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18.IL-33 is highly and selectively expressed by high endothelial venule endothelial cells (HEVECs) in human tonsils,Peyers's patches,and lymph nodes.It contains a bipartite nuclear localization signal at the C-terminus,and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs) and HeLa cells.The C-terminal fragment,corresponding to mature IL-33,binds and triggers signaling.IL-33 mediates its biological effects via Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2,activates NF-kappaB and MAP kinases,and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells.In vivo,IL-33 induces the expression of IL-4,IL-5,and IL-13 and leads to severe pathological changes in mucosal organs.Human IL-33 is 270 amino acids in length.
    来源E.coli
    溶剂Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
    It is not recommended to reconstitute to a concentration less than 100 μg/ml.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    内毒素Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.
    单位

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