P00055 Recombinant Human IL-3

Recombinant Human Interleukin-31 is produced by our E.coli expression system and the target gene encoding Ser24-Thr164 is expressed.

基本信息
基因名
别名	Interleukin-31;IL-31;IL31
外观(性状)	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度	≥95% as determined by reducing SDS-PAGE.
储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件	The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
背景说明	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure.It shares several structural and functional characteristics with IL-6，Oncostatin M，LIF，and Cardiotrophin-1.Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein.Human and mouse IL-31 share 24% sequence identity in the mature region.IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2).IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rβ).The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes.GPL/OSMR signaling is a strong activator of STAT3 and STAT5，and can also activate STAT1，Jak1，and Jak2 signaling pathways.IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
来源	E.coli
溶剂	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素	Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.
单位	支