P00050 Recombinant Human IL-1

Recombinant Human Interleukin-1 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Arg26-Glu177 is expressed.

基本信息
基因名
别名	Interleukin-1 Receptor Antagonist Protein;IL-1RN;IL-1ra;IRAP;ICIL-1RA;IL1 Inhibitor;Anakinra;IL1RN;IL1F3;IL1RA
外观(性状)	Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.
纯度	≥95% as determined by reducing SDS-PAGE.
储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件	The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
背景说明	Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family.Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases.It binds to IL-1 receptors in competition with IL-1，but does not elicit intracellular response from this binding.Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups.IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN.The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines.In synovial fibroblasts，IL-1，TNF-alpha，or PDGF markedly enhances the synthesis of IL-1RN.
来源	E.coli
溶剂	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素	Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.
单位	支