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- 2025年07月25日
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￥520
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现询
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北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥16896.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥11808.0 |
| 规格： | 50ug | 产品价格： | ￥1560.0 |
| 规格： | 10ug | 产品价格： | ￥520.0 |
Recombinant Human Interleukin-17A is produced by our E.coli expression system and the target gene encoding Ile20-Ala155 is expressed.
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Downregulation of Cathepsin B Reduces Proliferation and Inflammatory Response and Facilitates Differentiation in Human HaCaT Keratinocytes, Ameliorating IL-17A and SAA-Induced Psoriasis-Like Lesion
成员:Xu Di, Wang Jie
论文因子:4.092 发表期刊:INFLAMMATION pmid:34037897
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression
成员:Zhang Lihua, Guo Hui, Zhang Xiaoguang, Wang Ling, Wei Feng, Zhao Yike, Wang Bo, Meng Yibo, Li Yanling
论文因子:2.9 发表期刊:FUNCTIONAL & INTEGRATIVE GENOMICS pmid:38240925
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Nuclear translocation of PKM2 mediates keratinocyte metabolic reprogramming in psoriasis
成员:Luting Yang, Jie Zhang, Chunqing Hu, Xiaowen Chen, Yang Yang, Huihao Tang, Xiaolei Ding, Yaping Yan
论文因子:3.6 发表期刊:EXPERIMENTAL DERMATOLOGY pmid:37688280
| 基本信息 | |
| 基因名 | |
| 别名 | Interleukin-17A;IL-17;IL-17A;Cytotoxic T-Lymphocyte-Associated Antigen 8;CTLA-8;IL17A;CTLA8;IL17 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells.There are at least six members of the IL-17 family in humans and in mice.As IL-17 shares properties with IL-1 and TNF-alpha，it may induce joint inflammation and bone and cartilage destruction.This cytokine is found in synovial fluids of patients with rheumatoid arthritis，and produced by rheumatoid arthritis synovium.It increases IL-6 production，induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage.IL-17 is also able to increase bone destruction and reduce its formation.Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
| 来源 | E.coli |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Downregulation of Cathepsin B Reduces Proliferation and Inflammatory Response and Facilitates Differentiation in Human HaCaT Keratinocytes, Ameliorating IL-17A and SAA-Induced Psoriasis-Like Lesion
成员:Xu Di, Wang Jie
论文因子:4.092 发表期刊:INFLAMMATION pmid:34037897
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression
成员:Zhang Lihua, Guo Hui, Zhang Xiaoguang, Wang Ling, Wei Feng, Zhao Yike, Wang Bo, Meng Yibo, Li Yanling
论文因子:2.9 发表期刊:FUNCTIONAL & INTEGRATIVE GENOMICS pmid:38240925
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Nuclear translocation of PKM2 mediates keratinocyte metabolic reprogramming in psoriasis
成员:Luting Yang, Jie Zhang, Chunqing Hu, Xiaowen Chen, Yang Yang, Huihao Tang, Xiaolei Ding, Yaping Yan
论文因子:3.6 发表期刊:EXPERIMENTAL DERMATOLOGY pmid:37688280
Secretion of Recombinant Human Insulin-Like Growth Factor I (IGF-I)
The development of efficient recombinant protein production processes can be a critical factor in whether or not a pharmaceutical therapeutic protein can enter human clinical trials and ultimately the marketplace. This is especially true
Immunity：厦门大学韩家淮团队揭示 PELO 控制 NOD 样受体家族蛋白寡聚化组装和激活的机制
的炎症小体（Inflammasome），NOD2 等形成的 Nodosome，从而激活 NF-κB 通路、MAPK 通路、细胞焦亡等，释放 TNFα，IL-1β 和 IL-18 等炎性细胞因子，介导下游一系列免疫炎症级联反应【1,2】。这是机体最为基本的天然免疫防御反应之一，在机体清除病原感染和内源危险信号中发挥至关重要的作用。在人体中，多个 NLR 基因突变导致的异常激活也被发现参与了脓毒症、炎性肠病等多种重大炎性疾病的病理进程。 NLR 家族蛋白在结构上都含有一个核苷酸结合寡聚化结构域
又是代谢的锅，不治之症银屑病终于有盼头了！上交王宏林教授团队Immunity重磅报道
表明与正常鼠相比，PP6 缺陷的角质形成细胞高度增殖，更多地参与髓系细胞和 T 细胞的激活过程。这些结果表明，PP6 缺陷的角质形成细胞将促炎信号转导给免疫细胞。 富集分析表明，在 K5. Pp6fl/fl 鼠的皮损中 TNF 和 IL-17 信号被激活 (图 K)。半定量细胞因子阵列进一步证实了在 K5. Pp6fl/fl 鼠中，IL-23-T17 相关细胞因子的升高，包括 IL-23、IL-12p40、IL-22、IL-20、IL-6、TNF-α、IL-17A 和 IL-17F (图 M)。最后
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