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- Solarbio
- 北京
- IS0890
- 2026年04月14日
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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Sinigrin
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
3952-98-5
- 规格：
25mg/10mg/5mg
| 规格： | 25mg | 产品价格： | ￥1760.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥910.0 |
| 规格： | 5mg | 产品价格： | ￥530.0 |
| 基本信息 | |
| CAS | No.3952-98-5 |
| 中文名称 | 黑介子苷 |
| 英文名称 | Sinigrin |
| 别名 | Allylglucosinolate;2-Propenylglucosinolate;黑芥子苷钾盐;油菜 |
| 分子式 | C10H16NO9S2K·xH2O |
| 分子量 | 397.46(as Anhydrous) |
| 溶解性 | Soluble in Water/DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 223-545-8 |
| MDL | MFCD00149447 |
| SMILES | O[C@@H]1[C@@H](O)[C@H](S/C(CC=C)=N/OS(=O)(O[K])=O)O[C@H](CO)[C@H]1O |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 具有多种生理活性,可用于抗癌,抗炎,抗菌,抗真菌,抗氧化剂和伤口愈合的相关研究。 |
| 生物活性 | Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Sinigrin inhibits early-stage adipogenesis of 3T3-L1 adipocytes through the AMPK and MAPK signaling pathways. Sinigrin has potent anti-oxidant， anti-tumor and anti-inflammatory effects[1]. |
| In Vitro | Sinigrin remarkably inhibited the accumulation of lipid droplets and adipogenesis by downregulating the expression of CCAAT - enhancer - binding protein α (C/EBPα)， Peroxisome Proliferator - activated Receptor gamma (PPARγ)， Leptin and aP2. Sinigrin arrested cells in the G0/G1 phase of the cell cycle and increased the expression of p21 and p27. CDK2 expression was suppressed by sinigrin in MDI - induced adipocytes. Sinigrin increased the phosphorylation of adenosine monophosphate - activated protein kinase (AMPK)， mitogen - activated protein kinase (MAPK) and Acetyl - CoA Carboxylase (ACC) in the early stage of adipocyte differentiation， suggesting that sinigrin has anti - adipogenic effects through AMPK， MAPK and ACC activation.[1]。Cell Cycle Analysis[1]:Cell Line: 3T3-L1 adipocytes;Concentration:100 μg/mL;Incubation Time:24 h;Result:Arrested cells in the G0/G1phase of the cell cycle and increased the expression of p21 and p27.Western Blot Analysis[1]Cell Line: 3T3-L1 adipocytes;Concentration: 1， 10， and 100 μg/mL;Incubation Time:8 days;Result:Remarkably inhibited the accumulation of lipid droplets and adipogenesis by downregulating the expression of CCAAT-enhancer-binding protein α (C/EBPα)， PPARγ， leptin and aP2.RT-PCR[1]:Cell Line:3T3-L1 adipocytes;Concentration: 1， 10， and 100 μg/mL;Incubation Time:8 days;Result: Inhibited the production of pro-inflammatory cytokines including TNF-α and IL-6， IL-1β and IL-18. |
| 细胞实验 | Mice were orally administered with sinigrin (15 mg/kg or 30 mg/kg) for a period of 12 days in both prophylactic and therapeutic models. Sinigrin treatment (in both prophylactic and therapeutic models) significantly mitigated the DSS - induced body weight loss， attenuated the colon length shrinkage， and improved the disease index score (p < 0.001). Further results revealed that sinigrins protective/therapeutic effect is associated with a significant attenuation of pro?inflammatory cytokine production (p < 0.001)， reversing the anti - oxidant Enzyme levels (p < 0.001) and substantial improvement (2 folds) of the disruption of the colonic morphology in colon tissues compared to DSS control. Immunohistochemical analysis showed that sinigrin treatment remarkably reduced the DSS - induced myeloperoxidase， neutrophil Elastase， and CD68 expression in colon tissues. Additionally， sinigrin successfully abrogated the DSS - induced IL - 17 levels (p < 0.001) and improved the colonic barrier in colon tissues.[2];Dosage: 15 mg/kg or 30 mg/kg;Administration:Oral administration; for 12 days;Result:Significantly mitigated the DSS-induced body weight loss， attenuated the colon length shrinkage， and improved the disease index score. Successfully abrogated the DSS-induced IL-17 levels and improved the colonic barrier in colon tissues. |
| 数据来源文献 | [1]. Lee HW， et al. Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways. Biomed Pharmacother. 2018 Jun;102:670-680. [2]. Rama Satya Sri Kotipalli， et al. Sinigrin Attenuates the Dextran Sulfate Sodium-induced Colitis in Mice by Modulating the MAPK Pathway. Inflammation. 2023 Jun;46(3):787-807. |
| 单位 | 瓶 |
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IS0890 黑介子苷 抑制剂/拮抗剂/激动剂 索莱宝
￥530 - 1760
