- ¥1156
- CSN
- CSN11254
- 2025年10月13日
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- 详细信息
- 文献和实验
- 技术资料
- CAS号：
127191-97-3
- 供应商：
上海研卉生物科技有限公司
- 英文名：
KN-62
- 规格：
10mg
KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM..
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文献和实验transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available. Calbiochem的说明书。此抑制剂对3型JNK均有抑制作用，IC50有所区别。宣称对JNK的抑制比对ERK1和p38等的抑制要强300多倍。可是，这个应该是有争议的。作为JNK抑制剂起效快，但是特异性还有待研究。 提高特异性的另外一个选择是TAT JBD
Characterization of Calcium/Calmodulin- Stimulated Protein Kinase II
The enzyme Ca2+ /calmodulin-stimulated protein kinase II (CaM-PK II) belongs to a family of calmodulin-stimulated serine/threonine protein kinases that are widely distributed in nature, but are especially enriched in the brain (1 –3 ). CaM-PK
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)
The Ca2+ /calmodulin (CaM)-dependent protein kinase II (CaMKII) is a major regulator of synaptic plasticity. CaMKII function depends on complex regulation of its activity and localization by Ca2+ /CaM and several auto-phosphorylation
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