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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Sinapine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
18696-26-9
- 规格：
100mg/50mg/25mg/10mg/5mg
| 规格： | 100mg | 产品价格： | ￥4690.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥3390.0 |
| 规格： | 25mg | 产品价格： | ￥2390.0 |
| 规格： | 10mg | 产品价格： | ￥1540.0 |
| 规格： | 5mg | 产品价格： | ￥980.0 |
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Quantitative Proteomic Analysis Reveals the Mechanisms of Sinapine Alleviate Macrophage Foaming
成员:Aiyang Liu, Bin Liao, Shipeng Yin, Zhan Ye, Mengxue He, Xue Li, Yuanfa Liu, Yongjiang Xu
论文因子:4.6 发表期刊:MOLECULES pmid:36903257
| 基本信息 | |
| CAS | No.18696-26-9 |
| 中文名称 | 芥子碱 |
| 英文名称 | Sinapine |
| 分子式 | C16H24NO5 |
| 分子量 | 310.36 |
| 溶解性 | Soluble in DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | Light yellow to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| SMILES | C[N+](C)(C)CCOC(=O)C=CC1=CC(=C(C(=C1)OC)O)OC |
| InChIKey | HUJXHFRXWWGYQH-UHFFFAOYSA-O |
| InChI | InChI=1S/C16H23NO5/c1-17(2，3)8-9-22-15(18)7-6-12-10-13(20-4)16(19)14(11-12)21-5/h6-7，10-11H，8-9H2，1-5H3/p+1 |
| PubChem CID | 5280385 |
| 靶点 | P-glycoprotein |
| 通路 | Membrane Transporter&Ion Channel |
| 背景说明 | Sinapine是十字花科植物种子中的一种生物碱，具有良好的抗氧化等生物活性。Sinapine通过抑制FGFR4-FRS2α-ERK1/2信号通路，在下调P-gp表达中发挥重要作用。 |
| 生物活性 | Sinapine 是一种从十字花科物种的种子中分离出来的生物碱，具有具有抗炎和抗氧化作用作用。通过下调 P-glycoprotein 来抑制Caco-2细胞的增殖。[1-3] |
| In Vitro | Sinapine limited cytosolic oxidative stress in response to H2O2. Sinapine was able to blunt oxidative stress resulting from antimycin A-induced mtROS. Sinapine improved cardiac functional recovery following IR.[1] Sinapine increased the sensitivity of Caco-2 cells to doxorubicin in a dose-dependent manner. The combination of sinapine and doxorubicin had a synergistic effect and increased the cytotoxicity of doxorubicin against Caco-2 cells.[3] |
| 细胞实验 | Supplementation with sinapine reduced the body weight of HFD mice by 10.99%，and decreased the levels of TG and LDL-C by 15.67% and 73.62%. Sinapine also suppressed the intestinal NF-κB and TNF-α expressions and enhanced the adipose tissue IRS-1 expression in the HFD mice(P < 0.05). Sinapine induced a decrease in the ratio of Firmicutes to Bacteroidetes and increased the abundance of probiotics，such as Lactobacillaceae，Akkermansiaceae and Blautia，along with metabolite short-chain fatty acid(SCFA)-mediated upregulation of G protein-coupled receptor 43(GPR43)to inhibit expression of inflammatory factors.[2] |
| 数据来源文献 | [1]. Boulghobra D，et al. Sinapine，but not sinapic acid，counteracts mitochondrial oxidative stress in cardiomyocytes. Redox Biol. 2020 Jul;34:101554. [2]. Li Y ，Li J ，Su Q ，Liu Y . Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. Food Funct. 2019 Jun 19;10(6):3637-3649. [3]. Guo Y，et al. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food Chem Toxicol. 2014 May;67:187-92. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Quantitative Proteomic Analysis Reveals the Mechanisms of Sinapine Alleviate Macrophage Foaming
成员:Aiyang Liu, Bin Liao, Shipeng Yin, Zhan Ye, Mengxue He, Xue Li, Yuanfa Liu, Yongjiang Xu
论文因子:4.6 发表期刊:MOLECULES pmid:36903257
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