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- Solarbio
- 北京
- IL0480
- 2025年11月18日
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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Ligustroflavone
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
260413-62-5
- 规格：
1mg/10mg/5mg
| 规格： | 1mg | 产品价格： | ￥994.5 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥3561.5 |
| 规格： | 5mg | 产品价格： | ￥2116.5 |
Ligustroflavone 是一种潜在的钙敏感受体(CaSR) 拮抗剂。
| 基本信息 | |
| CAS | No.260413-62-5 |
| 中文名称 | 女贞苷 |
| 英文名称 | Ligustroflavone |
| 别名 | 女贞苷;ligustroflavone |
| 分子式 | C33H40O18 |
| 分子量 | 724.67 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | Light yellow to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22125004 |
| SMILES | O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@H](O[C@H](CO[C@H](O[C@@H](C)[C@H](O)[C@H]3O)[C@@H]3O)[C@@H](O)[C@@H]4O)[C@@H]4O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)=C6)C2=C6O |
| 靶点 | CaSR (calcium-sensing receptor) |
| 通路 | GPCR & G Protein |
| 背景说明 | Ligustroflavone 是一种潜在的钙敏感受体(CaSR) 拮抗剂。 |
| 生物活性 | Ligustroflavone is one major compound contained in active fraction from Fructus Ligustri Lucidi (the fruit of Ligustrum lucidum), which could regulate parathyroid hormone (PTH) levels and improve calcium balance by acting on calcium-sensing receptors (CaSR).Ligustroflavone could transiently increase PTH level and regulate calcium metabolism as well as prevent osteoporosis in diabetic mice, suggesting that ligustroflavone might be an effective antagonist on CaSR.[1] |
| In Vitro | LF interacted well with the allosteric site of CaSR shown by molecular docking analysis，increased PTH release of primary parathyroid gland cells and suppressed extracellular calcium influx in HEK-293 cells. [1] |
| 细胞实验 | The serum level of PTH attained peak value at 2 h and maintained high during the period of 1 h and 3 h than that before treatment in mice after a single dose of LF. Treatment of diabetic mice with LF inhibited the decrease in calcium level of serum and bone and the enhancement in urinary calcium excretion as well as elevated circulating PTH levels. Trabecular bone mineral density and micro-architecture were markedly improved in diabetic mice upon to LF treatment for 8 weeks. LF reduced CaSR mRNA and protein expression in the kidneys of diabetic mice. [1] |
| 数据来源文献 | [1]. Feng R， et al. Protective Effects of Ligustroflavone， an Active Compound from Ligustrum lucidum， on Diabetes-Induced Osteoporosis in Mice: A Potential Candidate as Calcium-Sensing Receptor Antagonist. Am J Chin Med. 2019;47(2):457-476. |
| 单位 | 瓶 |
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IL0480 女贞苷 抑制剂/拮抗剂/激动剂 索莱宝
￥994.50 - 3561.50
