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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Acacetin
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
480-44-4
- 规格：
10mg/5mg
| 规格： | 10mg | 产品价格： | ￥486.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥320.0 |
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Stability and antioxidant activity of phenolic compounds during in vitro digestion
成员:Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li
论文因子:3.9 发表期刊:JOURNAL OF FOOD SCIENCE pmid:36617678
| 基本信息 | |
| CAS | No.480-44-4 |
| 中文名称 | 金合欢素 |
| 英文名称 | Acacetin |
| 别名 | Linarigenin;5，7-dihydroxy-4-methoxyflavone;4-Methoxyapigenin |
| 分子式 | C16H12O5 |
| 分子量 | 284.26 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-552-3 |
| MDL | MFCD00016936 |
| SMILES | O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13 |
| InChIKey | DANYIYRPLHHOCZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3 |
| PubChem CID | 5280442 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | Acacetin是一类具有多种重要生理活性的黄酮类化合物,具有抗氧化、抗炎、抗癌的活性。 |
| 生物活性 | Acacetin (5，7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1-2]. |
| In Vitro | Acacetin(5，7-Dihydroxy-4'-methoxyflavone; 10-200 μM; 24 hours)decreases cell viabilities in a dose-dependent manner. Acacetin has little effect on human normal glial cell line HEB and non-tumorigenic epithelial cell line MCF-10A.Acacetin(50-150 μM; 24 hours)causes G2/M cell cycle arrest and induces apoptosis and autophagy.Acacetin(50-150 μM; 24 hours)leads to decreases in levels of PI3Kγ-p110，p-AKT，p-mTOR，p-p70S6K，and p-ULK in a dose-dependent manner[1]. |
| 细胞实验 | Acacetin(5，7-Dihydroxy-4'-methoxyflavone; 5，20 mg/kg/day; orally; for 3 days)significantly suppresses microglial activation in an LPS-induced neuroinflammation mouse model.Acacetin(25 mg/kg/day; orally; for 3 days)reduces neuronal cell death in an animal model of ischemia[2]. |
| 数据来源文献 | [1]. Hong-Wei Zhang， et al. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep. 2018 Jul 26;8(1):11255. [2]. Sang Keun Ha， et al. Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in vitro and in vivo. Neurochem Res. 2012 Jul;37(7):1560-7. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Stability and antioxidant activity of phenolic compounds during in vitro digestion
成员:Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li
论文因子:3.9 发表期刊:JOURNAL OF FOOD SCIENCE pmid:36617678
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