- ￥180 - 640
- Solarbio
- 北京
- IA1050
- 2025年12月26日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Asperosaponin Ⅵ
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
39524-08-8
- 规格：
1mg/10mg/5mg
| 规格： | 1mg | 产品价格： | ￥180.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥640.0 |
| 规格： | 5mg | 产品价格： | ￥390.0 |
研究表明，Asperosaponin VI 通过增加 Bcl-2/Bax 比值，降低活性 caspase-3 表达，以及增强 p-Akt 和 p-CREB，从而抑制缺氧诱导的心肌细胞凋亡。
| 基本信息 | |
| CAS | No.39524-08-8 |
| 中文名称 | 川续断皂苷Ⅵ |
| 英文名称 | Asperosaponin Ⅵ |
| 别名 | Akebia saponin D |
| 分子式 | C47H76O18 |
| 分子量 | 929.1 |
| 溶解性 | Soluble in Water/DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25371916 |
| SMILES | O[C@@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2[C@@](C)(CO)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(O[C@@H]7O[C@H](CO[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)[C@@H](O)[C@H](O)[C@H]7O)=O)[C@@]5([H])CC(C)(C)CC6)([H])[C@]4(C)CC2)OC1 |
| InChIKey | CCRXMHCQWYVXTE-HMRSNRLKSA-N |
| InChI | InChI=1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1 |
| PubChem CID | 14284436 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 研究表明,Asperosaponin VI 通过增加 Bcl-2/Bax 比值,降低活性 caspase-3 表达,以及增强 p-Akt 和 p-CREB,从而抑制缺氧诱导的心肌细胞凋亡。 |
| 生物活性 | Asperosaponin VI， A saponin component from Dipsacus asper， induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway[1]. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression， as well as enhancing of p-Akt and p-CREB.Asperosaponin VI (ASA VI)， a triterpene saponin isolated from Dipsacus asper Wall， has shown cardioprotective effects in vivo.[2]. |
| In Vitro | The assay of cell proliferation，alkaline phosphatase(ALP)activity and measurement of mineralized matrix，showed that ASA VI exhibited a significant induction of proliferation，differentiation and mineralization in MC3T3-E1 and primary osteoblastic cells. Induction of differentiation by ASA VI was associated with increased bone morphogenetic protein-2(BMP-2)，indicating that BMP-2 is essential in ASA VI to mediate osteoblast maturation and differentiation. In addition，ASA VI may induce differentiation by increasing the activity of p38 and ERK1/2. In conclusion，ASA VI may induce osteoblast maturation and differentiation，and then increase bone formation via increasing BMP-2 synthesis，and activating p38 and ERK1/2.[1] ASA VI significantly attenuated increased LDH and CK activities，and increased cell viability in hypoxia treated myocytes in a dose-dependent fashion. ASA VI treatment inhibited apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression，as well as enhancing of p-Akt and p-CREB. ASA VI had protective effect against hypoxia-induced cardiomyocytes apoptosis probably by activating the PI3K/Akt and CREB pathways.[2] |
| 数据来源文献 | [1]. Niu Y， et al. Asperosaponin VI， a saponin component from Dipsacus asper wall， induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway. Phytother Res. 2011 Nov;25(11):1700-6. [2]. Li C， et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7. |
| 单位 | 瓶 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验相关实验
2F+DwTquooTcizAj6Sh40arj1e+iWJ2ispgsbT801bWi9OaaVDQ0u7N9Rf22Q7je3ypEkT/aXtAx/4gHh20RbetchuWXizve3YY/3L0LGHHqt8Cva+97zf/vEfvyYb4imWXpTxLz8m4rvgjodswc3X26Xnn2o3LbjZPv/Fv5GGuGa33/ZzO2n2HD17NAEWeUXwmQh44uy32U+uutL+69e+6jjedfsddvSxx3m8xNNFQ67wipqQKHyESZ35
技术资料暂无技术资料 索取技术资料
IA1050 川续断皂苷Ⅵ 抑制剂/拮抗剂/激动剂 索莱宝
￥180 - 640
