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- 2025年12月22日
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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Desloratadine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
100643-71-8
- 规格：
25mg/50mg/100mg
| 规格： | 25mg | 产品价格： | ￥300.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥460.0 |
| 规格： | 100mg | 产品价格： | ￥720.0 |
| 基本信息 | |
| CAS | No.100643-71-8 |
| 中文名称 | 地氯雷他定 |
| 英文名称 | Desloratadine |
| 别名 | 地氯雷他定;脱羧氯雷他定 |
| 分子式 | C19H19ClN2 |
| 分子量 | 310.82 |
| 溶解性 | Soluble in DMSO ≥10mg/mL(Need ultrasonic) |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 638-878-8 |
| MDL | MFCD00871949 |
| SMILES | C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 |
| InChIKey | JAUOIFJMECXRGI-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2，5-6，9，12，21H，3-4，7-8，10-11H2 |
| PubChem CID | 124087 |
| 靶点 | Histamine Receptor |
| 通路 | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| 背景说明 | Desloratadine是一种有效的组胺H1受体拮抗剂。 |
| 生物活性 | Desloratadine is a new， selective， H(1)-receptor antagonist that also has anti-inflammatory activity.Desloratadine is a non-sedating， clinically effective， anti-allergic therapy that has been shown to exhibit anti-inflammatory properties that extend beyond its ability to antagonize histamine at H(1)-receptor sites.[1-2] |
| In Vitro | Desloratadine inhibits the release or generation of multiple inflammatory mediators，including IL-4，IL-6，IL-8，IL-13，PGD(2)，leukotriene C(4)，tryptase，histamine，and the TNF-alpha-induced chemokine RANTES. Desloratadine also inhibits the induction of cell adhesion molecules，plateletactivating factor-induced eosinophil chemotaxis，TNF-alpha-induced eosinophil adhesion，and spontaneous and phorbol myristate acetate-induced superoxide generation in vitro.[1] While capable of inhibiting histamine and LTC(4)release by human basophils，desloratadine is more effective at targeting the signals regulating IL-4 and IL-13 generation in these cells.[2] |
| 细胞实验 | Basophil-enriched suspensions were treated with various concentrations of desloratadine for 15 min before stimulating with either anti-IgE antibody，calcium ionophore，IL-3 or phorbol ester. Histamine(fluorimetry)，LTC(4)(RIA)and IL-4(ELISA)were all assayed using the same 4-h culture supernatants. IL-13(ELISA)was measured in supernatants harvested after 20 h incubation. IL-4 mRNA expression(dilutional RT-PCR)was also examined.[2] |
| 数据来源文献 | [1]. Geha， R.S. and E.O. Meltzer， Desloratadine: A new， nonsedating， oral antihistamine. J Allergy Clin Immunol， 2001. 107(4): p. 751-62. [2]. Schroeder， J.T.， et al.， Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy， 2001. 31(9): p. 1369-77. |
| 单位 | 瓶 |
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ID1770 地氯雷他定 抑制剂/拮抗剂/激动剂 索莱宝
￥300 - 720
