- ￥1704 - 3590
- Solarbio
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- IN3730
- 2026年01月16日
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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Norathyriol
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
3542-72-1
- 规格：
1mg/5mg
| 规格： | 1mg | 产品价格： | ￥1704.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥3590.0 |
| 基本信息 | |
| CAS | No.3542-72-1 |
| 中文名称 | 芒果苷元 |
| 英文名称 | Norathyriol |
| 别名 | 芒果 |
| 分子式 | C13H8O6 |
| 分子量 | 260.2 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD13689186 |
| SMILES | C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O |
| InChIKey | ZHTQCPCDXKMMLU-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4，14-17H |
| PubChem CID | 5281656 |
| 靶点 | α-glucosidases;PPAR |
| 通路 | Metabolic Enzyme&Protease;Cell Cycle;DNA Damage/DNA Repair |
| 背景说明 | Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase )。Norathyriol 还抑制 PPARα、PPARβ 和 PPARγ。 |
| 生物活性 | Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12?μM[1]. Norathyriol inhibits PPARα， PPARβ， and PPARγ with IC50s of 92.8 μM， 102.4 μM， and 153.5 μM， respectively[2]. Antioxidant， anticancer， antimicrobial， anti-inflammatory， anti-bacterial activities. |
| In Vitro | Norathyriol (1-25 μM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3].Norathyriol suppresses UVB-induced phosphorylation of ERKs， AP-1 and NF-κB activation in JB6 P+ cells[3] Cell Growth Assay WB.Cell Viability Assay[3]:Cell Line: Mouse skin epidermal JB6 P+ cells;Concentration:0， 1， 10， or 25 μM;Incubation Time:24 or 72 hours;Result:Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death.Western Blot Analysis[3]:Cell Line:JB6 P+ cells;Concentration:0， 1， 10， or 25 μM;Incubation Time:2 hours;Result:Inhibited UVB-induced phosphorylation of ERKs and p90RSK. |
| 细胞实验 | Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].Norathyriol (0.92， 1.85 and 3.7?mg/kg) dose dependently decreased the serum urate levels by 27.0， 33.6 and 37.4%， respectively[4].Animal Model:Adult Kunming mice weighing 18-22?g[4];Dosage: 0.92， 1.85 and 3.7?mg/kg;Administration:Administered intragastrically; twice daily for five times;Result:The serum uric acid levels were decreased by 27.0%， 33.6% and 37.4%. |
| 数据来源文献 | [1]. Zhi-Long Shi， et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015. [2]. Ashley S Wilkinson，et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42. [3]. Jixia Li， et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70. [4]. Yanfen Niu， et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6. |
| 单位 | 瓶 |
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IN3730 芒果苷元 代谢酶/蛋白酶 索莱宝
￥1704 - 3590
