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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
(S)-(-)-Bay-K-8644
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
98625-26-4
- 规格：
10mg/1mg/5mg
| 规格： | 10mg | 产品价格： | ￥1790.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥668.0 |
| 规格： | 5mg | 产品价格： | ￥1340.0 |
| 基本信息 | |
| CAS | No.98625-26-4 |
| 英文名称 | (S)-(-)-Bay-K-8644 |
| 分子式 | C16H15F3N2O4 |
| 分子量 | 356.3 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00153769 |
| SMILES | CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC |
| InChIKey | ZFLWDHHVRRZMEI-ZDUSSCGKSA-N |
| InChI | InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17，18)19/h4-7，13，20H，1-3H3/t13-/m0/s1 |
| PubChem CID | 6603728 |
| 靶点 | Calcium Channel |
| 通路 | Membrane Transporter&Ion Channel;Neuronal Signaling |
| 背景说明 | (S)-(-)-Bay-K-8644 是 L 型钙离子通道激动剂。 |
| 生物活性 | (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).[1-3] |
| IC50 | EC50: 32nM(IBa)[1] |
| In Vitro | (±)-Bay K 8644，a conventional racemic mixture of Bay K 8644，is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa(R(+)-Bay K 8644 as an antagonist and(S)-(-)-Bay-K-8644 as an agonist.(S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum[1]. The Ca2+ channel activity is enhanced by 3–30 μM(S)-(-)-Bay-K-8644 an agonist of L-type Ca2+ channels[2]. The interactions of two Ca2+ channel activators(S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176(300 nM)causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by(S)-(-)-Bay-K-8644(EC50=14 nM).(S)-(-)-Bay-K-8644(100 nM)increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176[3]. |
| 数据来源文献 | [1]. Zhu HL， et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15. [2]. Mironov SL， et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87. [3]. Rampe D， et al. Functional interactions between two Ca2+ channel activators， (S)-Bay K 8644 and FPL 64176， in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602. |
| 单位 | 瓶 |
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