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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: 2-8℃，2 years
- 保质期：
Powder: 2-8℃，2 years
- 英文名：
5-alpha-Dihydroprogesterone
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
566-65-4
- 规格：
1g/500mg/100mg
| 规格： | 1g | 产品价格： | ￥890.0 |
|---|---|---|---|
| 规格： | 500mg | 产品价格： | ￥590.0 |
| 规格： | 100mg | 产品价格： | ￥190.0 |
| 基本信息 | |
| CAS | No.566-65-4 |
| 中文名称 | 二氢Progesterone |
| 英文名称 | 5-alpha-Dihydroprogesterone |
| 别名 | 氢化Progesterone |
| 分子式 | C21H32O2 |
| 分子量 | 316.48 |
| 溶解性 | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| 纯度 | ≥97% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder: 2-8℃，2 years |
| EC | EINECS 209-297-3 |
| MDL | MFCD00067132 |
| SMILES | CC([C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O |
| InChIKey | XMRPGKVKISIQBV-BJMCWZGWSA-N |
| InChI | InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16-,17+,18-,19-,20-,21+/m0/s1 |
| PubChem CID | 92810 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是一种内源性的孕酮代谢物,可使肌动蛋白actin解聚,并降低 actin 和 vinculin 的表达。 |
| 生物活性 | The endogenous progesterone metabolite， 5a-pregnane-3，20-dione， decreases cell-substrate attachment， adhesion plaques， vinculin expression， and polymerized F-actin in MCF-7 breast cancer cells[1] |
| In Vitro | Treatment of cells with 10(-9)-10(-6)M 5alphaP resulted in dose-dependent decreases in cell area，cell-to-cell contacts，and attachment to the substratum，and increases in variation in nuclear area. These changes in the 5alphaP-treated cells were accompanied by decreases in vinculin-containing adhesion plaques，vinculin expression，polymerized actin stress fibers，and decreases in insoluble and increases in soluble actin fractions. The results suggest that the observed decreases in adhesion and increases in cell proliferation following 5alphaP treatment may be owing to depolymerization of actin and decreased expression of actin and vinculin. [1] |
| 细胞实验 | To determine the mechanisms of action of 5alphaP on cell adhesion，MCF-7 cells were grown without or with 5alphaP(10(-9)-10(-5)M)，and the effects on cell and nuclear morphology，adhesion plaques，vinculin and actin expression，actin polymerization，and microfilament distribution were examined by immunohistochemistry，morphometry(using confocal microscopy and digital computer imaging analysis)，and Western blotting.[1] |
| 数据来源文献 | [1]. Wiebe JP， et al. The endogenous progesterone metabolite， 5a-pregnane-3，20-dione， decreases cell-substrate attachment， adhesion plaques， vinculin expression， and polymerized F-actin in MCF-7 breast cancer cells. Endocrine. 2001 Oct;16(1):7-14. |
| 单位 | 瓶 |
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文献和实验, we may find much more references regarding this issue. http://books.google.com/books?id=3mgPzNFjcWAC&pg=PA51&lpg=PA51&dq=gsk+tyrosine+phosphorylation+and+activity&source=bl&ots=x5ueTldpez&sig=CqRFJleXtEBn9OfelhODPAc28xs&hl=en&ei=KerNSu-XGcem8Abm-qmABA&sa=X&oi=book_result&ct
)及磷脂过氧化氢谷胱甘肽氧化酶(PHGSH�x)的组成成分。GSH�x中每克分子酶四聚体含有4克原子硒，硒半胱氨酸的硒醇是酶的催化中心。该酶在人体内起抗氧化作用，能催化GSH与胞液中的过氧化物反应，防止过氧化物对机体的损伤。GSH�x活力下降，线粒体不可逆地失去容积控制和收缩能力并最后破裂。缺硒所致肝坏死可能是过氧化物代谢受损的结果。PHGSH�x与GSH�x不同，它存在于肝和心肌细胞线粒体内膜间隙中，作用是抗氧化、维持线粒体的完整，避免脂质过氧化物伤害。此外，I型碘甲腺原氨酸5′－脱碘酶(5′�ID
of complex and protein alone with the naked eye or a light microscope, crystals of covalently Cy5?labeled DNA can be directly used for X?ray diffraction data collection. Curr. Protoc. Nucleic Acid Chem. 46:7.15.1?7.15.8. © 2011 by John Wiley & Sons
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