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- 2025年07月23日
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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Bivalirudin TFA
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
128270-60-0
- 规格：
100mg/50mg/20mg
| 规格： | 100mg | 产品价格： | ￥1800.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥1300.0 |
| 规格： | 20mg | 产品价格： | ￥960.0 |
| 基本信息 | |
| CAS | No.128270-60-0 |
| 中文名称 | 比伐卢定TFA盐 |
| 英文名称 | Bivalirudin TFA |
| 别名 | ;比伐卢定;比瓦尔丁;比伐芦定;TFA比伐卢定，TFA比伐芦定;TFA比伐卢定; |
| 分子式 | C98H138N24O33·C2HF3O2 |
| 分子量 | 2294.3 |
| 溶解性 | Soluble in Water ≥10mg/mL |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 274-570-6 |
| SMILES | CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]5CCCN5C(=O)[C@@H](CC6=CC=CC=C6)N |
| 靶点 | Thrombin |
| 通路 | Metabolic Enzyme&Protease |
| 背景说明 | 是一种凝血酶 (thrombin) 抑制剂。 |
| 生物活性 | Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin. [1] Bivalirudin-facilitated binding of MPO to BAEC resulted also in functional changes in terms of increased NO consumption as well as enhanced MPO-mediated redox modifications [3]. |
| In Vitro | IC50 Value: Target: thrombin in vitro: Eptifibatide(8 mg/mL)added together with a low(70 ng/mL)concentration of bivalirudin(a direct thrombin inhibitor)effectively(approximately 90%)reduced platelet aggregation induced by thrombin(0.2 U/mL)[1]. In thrombin generation assay(TGA)，bivalirudin had no effect on these parameters up to 10 μmol/l [2]. |
| 细胞实验 | in vivo: The use of bivalirudinprevented further increase in antiheparin/PF4 antibody IgG levels in rats [4]. |
| 动物实验 | Three animals in the 500-mg/kg/24 h group，and 7 animals in the 2000-mg/kg/24 h group in the toxicokinetic assessment phase of the study were found dead or euthanized in extremis(following blood sampling). Plasma concentrations of bivalirudin appeared to be linear and dose independent [5]. |
| 数据来源文献 | [1]. Ciborowski M， Tomasiak M. The in vitro effect of eptifibatide， a glycoprotein IIb/IIIa antagonist， on various responses of porcine blood platelets. Acta Pol Pharm. 2009 May-Jun;66(3):235-42. [2]. Xu Y， Wu W， Wang L， Differential profiles of thrombin inhibitors (heparin， hirudin， bivalirudin， and dabigatran) in the thrombin generation assay and thromboelastography in vitro. Blood Coagul Fibrinolysis. 2013 Apr;24(3):332-8. [3]. Rudolph V， Rudolph TK， Schopfer FJ， Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase. J Pharmacol Exp Ther. 2008 Nov;327(2):324-31. [4]. Zhang R， Huang Y， Zhang M， Bivalirudin Utilization in Rats Undergoing Cardiopulmonary Bypass: Preventing the Increase of Antiheparin/Platelet Factor 4 Antibody in Perioperative Period. Clin Appl Thromb Hemost. 2012 Aug 21. [Epub ahead of print] [5]. Gleason TG， Chengelis CP， Jackson CB， A 24-hour continuous infusion study of bivalirudin in the rat. Int J Toxicol. 2003 May-Jun;22(3):195-206. |
| 单位 | 瓶 |
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IB2860 比伐卢定TFA盐 Peptides 索莱宝
￥960 - 1800
